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Community-Based Methods for Preventing Dental Caries and Periodontal Disease
Published in Lars Granath, William D. McHugh, Systematized Prevention of Oral Disease: Theory and Practice, 2019
Other formulations of fluoride-containing dentifrices have also been successfully tested. These include stannous fluoride/insoluble metaphosphate,14,70,96 sodium monofluorophosphate with several different abrasive systems;28,31,35,47,61,65,71,78,100 stannous fluoride in a hydrated silica gel formulation;29 amine fluoride;24,30,54 and sodium fluoride.8,108,111,112
Periodontal Disease
Published in Kohlstadt Ingrid, Cintron Kenneth, Metabolic Therapies in Orthopedics, Second Edition, 2018
Fluoride irrigation solutions should not be applied as they have been shown to promote destruction of bone in the presence of preexisting PD [28]. The mouth has a thin mucosa, especially the floor of the mouth, and superb circulation; therefore, it can be used to supply nutrients such as vitamin B12 directly to the blood stream. By the same logic, a dentifrice that contains fluoride will give an unwanted systemic dose and impact the integrity of the jawbone. Inflammation is a known result of exposing soft tissues to fluoride. The patent application of a pharmaceutical company discloses that concentrations of fluorides from fluoridated toothpastes and mouthwashes activate G proteins in the oral cavity, thereby promoting PD and oral cancer. This is not surprising considering that research has linked fluoride to g protein activation [29].
Glycerine in Oral Care Products
Published in Eric Jungermann, Norman O.V. Sonntag, Glycerine, 2018
Glycerine is employed as a formulation aid in both OTC and prescription items for care of the oral cavity. Primary applications are in dentifrices, oral rinses, and dental gels [1]. A dentifrice has been defined as a substance used with a toothbrush to clean the accessible surfaces of the teeth. Current dentifrices also play the important role of acting as vehicles for delivery to the oral cavity of therapeutic and cosmetic agents, such as fluoride for anticaries activity and pyrophosphates for antitartar effect. An oral rinse, or mouthwash, has historically been defined as a solution containing breath-sweetening, astringent, demulcent, detergent, or germicidal agents which is used for freshening or cleaning the mouth or for gargling. Today’s oral rinses are frequently the vehicles for the delivery of active agents, cosmetic or therapeutic, to the oral mucosa or dental hard tissues. The terms “oral rinse” and “dental rinse” are preferred to “mouthwash” by some according to their respective areas for use, viz. oral mucosa or the teeth, respectively. A new type of dental rinse was introduced to the market a few years ago, a prebrushing dental rinse, for rinsing prior to toothbrushing, to remove and loosen some dental plaque initially and leave it in condition for ready removal by the toothbrush subsequently. The term “dental gel” is usually used to distinguish a dosage form for the delivery of an anticaries agent to aid in the prevention of tooth decay. The dental gel does not contain dental abrasives. It is usually applied by the dentist or dental hygienist.
Enhancement of chlorhexidine activity against planktonic and biofilm forms of oral streptococci by two Croton spp. essential oils from the Caatinga biome
Published in Biofouling, 2022
Brendda Miranda Vasconcelos, Antônio Mateus Gomes Pereira, Paulo Adenes Teixeira Coelho, Rafaela Mesquita Bastos Cavalcante, Daniela Santos Carneiro-Torres, Paulo Nogueira Bandeira, Felipe Ferreira da Silva, Tigressa Helena Soares Rodrigues, Geovany Amorim Gomes, Victor Alves Carneiro
Despite global efforts, the widespread prevalence of caries disease suggests that the antimicrobial methods used for biofilm control have limitations (Lee et al. 2016; Bescos et al. 2020). In particular, the prolonged use of the gold standard oral antiseptic chlorhexidine digluconate (CHX) against biofilm and oral infections can cause adverse effects such as cytotoxicity, genotoxicity, and resistant strain selection (Kaspar et al. 2019; Takenaka et al. 2019; Brookes et al. 2020). Thus, new approaches are necessary to replace or improve chemical anti-plaque agents present in mouth rinses or dentifrices to control microbial accumulation on teeth surfaces. Plant-derived products, such as essential oils (EOs), have attracted attention due to their ability to eradicate microorganisms and inhibit biofilm formation (Song et al. 2018; Carneiro et al. 2020; Albuquerque et al. 2021). Studies have shown that Eos can affect the bacterial cell wall and membrane structure, leading to increased bacterial permeability and resulting in the loss of cellular constituents (Oussalah et al. 2006; Nazzaro et al. 2013; Kachur and Suntres 2020). Several EO-producing plants with antimicrobial activity are widely distributed in Caatinga’s Brazilian biome, such as Croton spp. (Araújo et al. 2014; Cordeiro et al. 2015; Rocha et al. 2021).
Nanoencapsulated fluoride as a remineralization option for dental erosion: an in vitro study
Published in Acta Odontologica Scandinavica, 2021
Juliane Rolim de Lavôr, Nayanna Lana Soares Fernandes, Elizabeth Barreto Galvão de Sousa, Juliellen Luiz da Cunha, Ingrid Andrade Meira, Fábio Correia Sampaio, Andressa Feitosa Bezerra de Oliveira
The availability of fluoride in dentifrices is considered an important factor to its protective and/or remineralizing potential [27]. In this study, for comparative purposes, without using nanotechnology, we used fluoridated dentifrices containing potassium nitrate (PN) and arginine (AG), which are indicated for the treatment of erosive lesions by the manufacturers. PN dentifrice was developed to limit potential interactions with excipients and, therefore, provide high levels of bioavailable fluoride [28]. The surface microhardness remineralization found for PN in this investigation is in accordance with the findings described by Zawaideh et al. [4], Fita & Kaczmarek [13], Lacerda [14] and Zanatta et al. [33]. In contrast, Kato et al. [34] and Faller et al. [35] reported that this product had the greatest surface loss.
A Dual Zinc plus Arginine formulation attenuates the pathogenic properties of Porphyromonas gingivalis and protects gingival keratinocyte barrier function in an in vitro model
Published in Journal of Oral Microbiology, 2020
Amel Ben Lagha, Ying Yang, Harsh M. Trivedi, James G. Masters, Daniel Grenier
Zinc oxide and zinc citrate trihydrate were obtained from U.S. Zinc (Houston, TX, USA) and Jost Chemical (St. Louis, MO, USA), respectively. L-arginine (free form) was purchased from Ajinomoto (Tokyo, Japan). A mixture containing 0.96% zinc (zinc oxide, zinc citrate) and 1.5% arginine was freshly prepared in sterile distilled water and is referred to as the Dual Zinc plus Arginine aqueous solution. Unless indicated otherwise, the Dual Zinc plus Arginine aqueous solution was used at dilutions of 1/500, 1/1000, and 1/2000 (v/v). A dentifrice containing 0.96% zinc (zinc oxide, zinc citrate), 1.5% arginine, and 1450 ppm fluoride as sodium fluoride in a silica base marketed by Colgate-Palmolive Co. (Toronto, Canada) as Colgate Total toothpaste formula was also used. A zinc- and arginine-free control fluoride dentifrice was also tested. Unless indicated otherwise, the Dual Zinc plus Arginine dentifrice and control fluoride dentifrice were used at dilutions of 1/500, 1/1000, and 1/2000 (w/v). At the dilutions used, the amounts of zinc and arginine in the Dual Zinc plus Arginine aqueous solution and the Dual Zinc plus Arginine dentifrice were comparable. The pH of the aqueous solution was 10, while that of the dentifrice was 8.2; however, at the dilutions used, the buffer capacity of the culture tissue medium and the assay solutions brings the final pH at around 7.2. When the Dual Zinc plus Arginine aqueous solution and dentifrice were inoculated onto Todd-Hewitt agar plates (THA; Becton, Dickinson and Company, Sparks, MD, USA), no microbial contamination was observed (data not shown).