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Honey and Its Immunostimulatory Activities
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Honey is a well-recognised therapy for symptoms of upper respiratory tract infection. Guidelines advised honey in children for acute cough. Honey probably alleviates the symptoms of upper respiratory tract infections, with the powerful manifestation in the context of severity and frequency of cough. Lots of verifications encourage its consumption in preference over regular care for other symptoms of upper respiratory tract infections, and lots of verifications emerge from research studies among children. Honey is a regularly consumed remedy that is well identified by patients. Honey is less harmful and more efficient in contrast with usual alternative care, and it doesn't cause any microbial resistance (Abuelgasim et al., 2021).
Natural Products in the Treatment of Unremitting Wounds Secondary to Diabetes or Peripheral Vascular Disease
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Wound management has employed natural topical agents for centuries. Honey for medicinal purposes has been referenced on Sumerian clay tablets dating from 1250–1900 BC, in ancient Egyptian and Greek times, and by Hippocrates to clean wounds (Chepulis, 2008). Medicinal honey remains a widespread natural topical agent for wound management today. The bioactivity of honey to promote healing within cutaneous wounds is multifocal, including having antibacterial, antioxidant and anti-inflammatory effects. Honey thus acts as a debriding agent and stimulates tissue growth (Oryan, Alemzadeh, and Moshiri, 2016). Improved wound healing may be due to an increased number of keratinocytes with the application of topical honey (Majtan, Kumar, Majtan, Walls, and Klaudiny, 2010). Increased epithelialization within wound beds and a decrease in scar formation have been found with the use of topical honey (Al-Waili, Salom, and Al-Ghamdi, 2011). Manuka honey was shown to assist wound healing through the stimulation of monocytes that differentiate into macrophages and thus release TNF-α (Tonks, Cooper, Price, Molan, and Jones, 2001).
Animal Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Honey is a viscous liquid and has a very complex chemical composition that varies depending on the botanical source. Today, there are approximately 300 types of honey in the world (133). These varieties are related to the different types of nectar collected by the honeybees. Depending on its origin, honey can be classified in different categories among which monofloral honey seems to be the most promising and interesting as a natural remedy. Manuka honey, a monofloral honey obtained from the manuka tree (Leptospermum scoparium) of the Myrtaceae family, which grows as a shrub or a small tree throughout New Zealand and eastern Australia, has greatly attracted the attention of researchers for its biological properties, especially its antimicrobial and antioxidant capacities (134).
Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis
Published in Drug Delivery, 2023
Amal M. Sindi, Waleed Y. Rizg, Muhammad Khalid Khan, Hala M. Alkhalidi, Waleed S. Alharbi, Fahad Y. Sabei, Eman Alfayez, Hanaa Alkharobi, Mohammed Korayem, Mohammed Majrashi, Majed Alharbi, Mohammed Alissa, Awaji Y. Safhi, Abdulmajeed M. Jali, Khaled M. Hosny
The data in Table 6 show that F2 (i.e. the optimum ItZ-ThO-SNEDDS-loaded gel) had the lowest ulcer index. It was comparable to that of the negative control group, which received normal saline, and Group 3, which received plain gel. This finding revealed the substantially low ulcer-forming capacity of F2. Such noticeable activity might be ascribed to the nature of the gel base carrying F2, which had honey among its components. Honey has certain physical traits that encourage its application as a medicinal drug to fight certain infections (Hixon et al., 2019). These characteristics of honey are also connected to its ability to reduce inflammation and promote wound healing, antioxidant and the capacity to scavenge free radicals. It is an immune stimulator that can improve the immunological response (Almasaudi et al., 2016). It can be used to treat a variety of ulcers; it can also be utilized for wound healing and skin sanitation. In addition to its anti-inflammatory and bacteria-fighting capabilities, it accelerates the healing of wounds and reduces the ulcer index (Almasaudi et al., 2017).
Infant botulism: an underestimated threat
Published in Infectious Diseases, 2021
Luca Antonucci, Cristian Locci, Livia Schettini, Maria Grazia Clemente, Roberto Antonucci
Traditionally, honey is considered the main avoidable risk factor for IB. In fact, a high percentage of affected children has a history of consumption of honey before the onset of illness in the US, [55] and other countries [58–60]. In Europe and in other geographic areas, around 60% of IB cases continue to have a positive history of exposure to honey [55,58]. Therefore, according to the Advisory Committee on the Microbiological Safety of Food, honey should not be given to children under one year of age [61]. However, it is probably not the main environmental source [55] as C. botulinum spores have been found in just 2–24% of honey samples [62,63]. The correspondence between the species of C. botulinum isolated in patients and those present in the domestic or soil dust supports the role of other spore sources [64–66]. Indeed, living near or having a parent who works in a farm, building site, windy and dry area where there is potential for soil disruption are major risk factors for IB [67]. Additional food sources of C. botulinum include formula milk powder [68,69], and herbal infusions such as chamomile, anise and mint [64].
Associations between honey consumption and prehypertension in adults aged 40 years and older
Published in Clinical and Experimental Hypertension, 2020
Shunming Zhang, Zuolin Lu, Chunling Tian, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Yeqing Gu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Zhong Sun, Kun Song, Kaijun Niu
In recent years, supplementation of various nutrients has become a novel option for lowering blood pressure (BP) in prehypertension (5,6). Honey is a sweet and flavorful natural health food produced by honeybees, which collect from plant nectars, plant secretions, or secretions of aphids (7). Studies have demonstrated that honey has numerous medicinal benefits, including obesity control (8), treatment of diabetes mellitus (9), wound-healing properties (10), anti-cancer effects and positive-cardiovascular effects (11). A recent review also showed that honey has antihypertensive effects based on clinical and preclinical studies, but the association between honey and prehypertension has not been reported (12). Furthermore, evidences have also shown that honey contains antioxidant and anti-inflammatory agents (11,13,14). These effects have been attributed largely to the numerous types of phytochemicals (e.g., flavonoids and polyphenols) present in honey (11,15).