Ameloblastic carcinoma – Knowledge and References

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Odontogenic Tumors

Published in Dongyou Liu, Tumors and Cancers, 2017

Diagnosis of odontogenic tumors, lesions and cysts is largely based on imaging and histopathologic features. Among malignant odontogenic tumors, ameloblastic carcinoma shows sheets, islands, or trabecular epithelium of round, spindled to tall columnar cells, with overtly malignant cytologic features (i.e., nuclear pleomorphism, mitotic activity of two mitoses in a high power field, focal necrosis, and nuclear hyperchromasia). Ameloblastic carcinoma with a limited atypia or intermediate grade cytologic features is designated as “atypical ameloblastoma.” SOX2 may be used in conjunction with Ki-67 for differentiation of ameloblastic carcinoma from ameloblastoma and atypical ameloblastoma.

Ameloblastoma: a retrospective single institute study of 34 subjects

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Journal Information

Published in Acta Odontologica Scandinavica, 2019

Jetta Kelppe, Jaana Hagström, Timo Sorsa, Anna Liisa Suominen, Satu Apajalahti, Caj Haglund, Hanna Thorén

To our knowledge, other Norther European studies focusing on clinical data of ameloblastomas do not exist. A collective study of Scandinavian patients with ameloblastoma would give scientifically more reliable insight into Nordic patients with ameloblastoma. Furthermore, it would be interesting to study how many patients with ameloblastoma develop a metastasizing ameloblastoma or an ameloblastic carcinoma. For this, as well, a collective Scandinavian cohort would be beneficial.