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Breast Thermography
Published in James Stewart Campbell, M. Nathaniel Mead, Human Medical Thermography, 2023
James Stewart Campbell, M. Nathaniel Mead
“Alternative” medical treatments are not always safe or benign. The thermographer may encounter patients who have self-treated palpable breast masses with escharotic salves, on the theory that chemically burning the overlying skin will “dissolve” the underlying mass. These salves often contain bloodroot (Sanguinaria canadensis) or other topically toxic ingredients. If used over a period of time, escharotics kill the dermis, leaving a full-thickness denuded wound that appears very warm to thermal imaging (Figure 9.30). This inflamed wound obscures any thermal findings from the underlying mass, making breast thermography useless until the area heals completely. Ultrasonography, X-ray mammography, or breast MRI may be required to determine the nature of any masses.
Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Sanguinarine (Figure 12.25) is a benzophenanthridine quaternary ammonium salt alkaloid isolated from the Papaveracea family of plants such as Sanguinaria canadensis (bloodroot), Argemone mexicana (Mexican prickly poppy), Chelidonium majus, and Macleaya cordata. It is also found in the leaves, stem, and root of Fumitory species of the opium poppy (i.e., papaveraceae), but not in the capsule. It contains a positively charged quaternary nitrogen grouping in one of its central rings, and is one of the most widely researched benzophenanthridine alkaloids. Structure of the alkaloid sanguinarine.
Identification, Cultivation, and Conservation: Botanical and Agricultural Resources
Published in David J. Owen, The Herbal Internet Companion, 2001
One unfortunate consequence of the recent resurgence of interest in herbal medicine is the overharvesting of plants from their native habitats. The National Center for the Preservation of Medicinal Herbs is a not-for-profit research facility and preserve located in Meigs County, Ohio. It cultivates and studies medicinal herbs at risk of extinction due to excessive harvesting, such as bloodroot (Sanguinaria canadensis) and goldenseal (Hydrastis canadensis L.). This site provides valuable information on cultivation and preservation issues, including current research projects designed to tackle these problems (also see the related entry in this chapter for United Plant Savers). National Technical Information Service (NTIS) <http://www.ntis.gov/>
In vitro anti-biofilm efficacy of sanguinarine against carbapenem-resistant Serratia marcescens
Published in Biofouling, 2021
Yuting Fu, Wanting Liu, Miao Liu, Jianing Zhang, Min Yang, Ting Wang, Weidong Qian
Plant-derived products are increasingly attracting widespread attention, in particular for their promising antibacterial/anti-biofilm effects (Yu et al. 2018). Sanguinarine (C20H14NO4+) is a natural plant-derived benzophenanthridine alkaloid extracted mainly from the bloodroot plant Sanguinaria canadensis, which exhibits diverse pharmacological activities, such as antimicrobial, anti-inflammatory, and anti-cancer activities (Kuttikrishnan et al. 2019). The methods available for sanguinarine extraction from plants include maceration, microwave-assisted extraction (MAE), ultrasound-assisted extraction and percolation, of which MAE was determined to be the most effective method and was capable of yielding 17.10 ± 0.4 mg g−1 sanguinarine from fruits of Macleaya cordata (Willd) R. Br. (Zhang et al. 2005). Furthermore, sanguinarine can potently inhibit several pathogens, including Staphylococcus aureus, Escherichia coli and Psoroptes cuniculi (Obiang-Obounou et al. 2011; Zhong et al. 2017). However, to date, the antibacterial and anti-biofilm activities of sanguinarine against carbapenem-resistant S. marcescens have not been studied. This study aimed mainly to assess the anti-biofilm activity of sanguinarine against CRSM, along with its underlying antibacterial mode of action.
Black salve treatment of skin cancer: a review
Published in Journal of Dermatological Treatment, 2018
Zinc chloride and bloodroot, contained in salve formulations, are two of the most well-known escharotic agents. Zinc chloride has been used to debride chronic leg ulcers and osteomyelitis bone (22,23). Bloodroot contains sanguinarine, a benzylisoquinolone alkaloid derived from the Sanguinaria canadendis plant species. Sanguinarine has been demonstrated to show antimicrobial, anti-inflammatory, antioxidative and immunomodulatory effects (2,24). There is emerging data that sanguinarine has therapeutic benefit against cancer.
Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases
Published in Journal of Drug Targeting, 2022
Qiang Xu, Zhiyou Cao, JiaQiang Xu, Min Dai, Bin Zhang, Qi Lai, Xuqiang Liu
Sanguinarine, an alkaloid derived from the roots of Sanguinaria canadensis, suppresses RANKL-induced osteoclast formation and function by decreasing the expression of TRAP, CTSK, CTR, DC-STAMP, V-ATPase d2, NFATc1, and c-Fos, IκBα phosphorylation and degradation, and ERK phosphorylation [118].