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Ozone Therapy in Oncology Patients
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
The oxygen supply to the tissues improves after ozone therapy. These effects respond to different mechanisms, and there are several experimental pointers to confirm this phenomenon. Ozone therapy reverses the erythrocyte aggregation of occlusive arterial diseases by changes in the electric charges of the erythrocyte membrane. The increase in the rate of glycolysis in the erythrocyte is accompanied by a significant increase in the exchange of sodium and potassium ions, which are responsible for maintaining the membrane electrical potential, normalizing the exchange of such ions. Occlusive arterial diseases are related to the loss of the normal potential of the erythrocyte plasmatic membrane. The normalization of ion exchange by ozone and its products favors the restoration of normal membrane potential. Accordingly, through regeneration of the normal electrical conditions of the membrane, ozone promotes the recovery of the flexibility and plasticity of the erythrocytes, thus improving the rheological properties of the blood and improving oxygen transport. In addition, during the treatment with ozone, a lower settling velocity is observed, with a decrease in viscosity, which explains the improvement in hemorrhagic indicators of these patients [1–5].
Hyperthermia in oncology and nontoxic integrative treatments
Published in Clifford L. K. Pang, Kaiman Lee, Hyperthermia in Oncology, 2015
Clifford L. K. Pang, Kaiman Lee
Medical ozone therapy on vaginal infection is sufficiently successful. For each patient, an appropriate therapy is necessary. Medical ozone therapy has obvious effects on the cure and prevention of chronic pelvic inflammatory disease, vaginal cancer, cervical cancer, ovarian cancer, and adnexal carcinoma. Medical ozone therapy applied to patients treated with radiotherapy or chemotherapy can strengthen the effect of radiotherapy and chemotherapy, can relieve toxic and side effects, and has obvious prevention effect on enteritis and vaginitis caused by radiotherapy and chemotherapy.
Effect of ozone versus naringin on testicular injury in experimentally induced ulcerative colitis in adult male albino rats
Published in Ultrastructural Pathology, 2022
Abeer M. Azmy, Bassant T. Abd Elbaki, Mohammed A. Ali, Abeer A Mahmoud
Natural gas ozone has no color and a characteristic odor when it is at room temperature.21 After being administered, ozone therapy (OT) dissolves in biological fluids and activates antioxidant systems.22 Ozone treatment uses a mixture of ozone and oxygen, which is both safe and affordable for the treatment of different physiopathologic events mediated by reactive oxygen species (ROS).23 Ozone therapy, in contrast to pharmacological treatment, promotes disease resistance by triggering the body’s antioxidant and anti-inflammatory pathways.24 Immune modulations, neoangiogenesis, and improved tissue oxygenation are ozone’s other significant effects.25 Research has specifically investigated at how ozone therapy can prevent testis damage caused by a variety of methods by decreasing levels of apoptosis and oxidative stress.26
Effects of subcutaneous injection of ozone during wound healing in rats
Published in Growth Factors, 2019
Ciro D. Soares, Thayná M. L. Morais, Roberta M. F. G. Araújo, Patrícia F. Meyer, Eric A. F. Oliveira, Rodrigo M. V. Silva, Eneida M. Carreiro, Edvaldo P. Carreiro, Verônica G. Belloco, Bruno A. L. A. Mariz, Jacks Jorge-Junior
In addition, it has been demonstrated that ozone therapy increased tissue oxygenation and metabolism, interfering in the oxidant/antioxidant balance (Travagli et al. 2010; Viebahn-Hänsler et al. 2012). Based on this mechanism, ozone is capable of regulating a previous disturbed oxidant/anti-oxidant scenario, reducing H2O2 levels, and regulating antioxidant molecule levels (Viebahn-Hänsler et al. 2012). Furthermore, ozone-produced peroxides cause an improvement in oxygen release and availability by regulating antioxidant molecules such as SOD and G-6PH in red blood cells, favoring the metabolism and release of cytokines, autacoids, and growth factors, which, together with the antimicrobial activity, are fundamental elements in the treatment of metabolic, inflammatory, and infectious diseases (Travagli et al. 2010). It has also been suggested that the action of ozone therapy may be interpreted as a nontoxic “therapeutic shock” capable of restoring homeostasis as a physiological response modifier (Bocci et al. 2009, 2011; Valacchi et al. 2005). Despite some evidence favoring ozone therapy effectiveness, it is not yet present in the routine of ulcer treatments, which would be an interesting and low-cost adjuvant therapy.
ALSUntangled #68: ozone therapy
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2023
Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Paul Wicks, Richard Bedlack
Ozone therapy has possible mechanisms for treating ALS. A preclinical study in very small numbers of mTDP43 mice (which has yet to be peer-reviewed) suggested benefits on motor function and survival (21,22); however, these benefits were not seen in mSOD1 mice (20). One verified “ALS reversal” occurred on a cocktail of alternative therapies including ozone (24); an association such as this does not prove causality. There have been no trials of ozone therapy in PALS. There may be potentially serious side effects associated with ozone therapy, depending on the dose (31). Based on all this, we support further investigation of ozone therapy in ALS cell or animal models, but we cannot yet recommend it as an ALS treatment.