China
Africa
Explore chapters and articles related to this topic
Ozone Therapy in Oncology Patients
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
The therapeutic properties of ozone are basically conditioned by two independent mechanisms: Direct oxidizing capacity: Its great oxidizing power makes it react directly with microbial walls and exert its germicidal effects or, for example, makes it react directly with mediators of inflammation and pain or cytokine receptors and block biological responses [1,4].Indirect effects: These are related to those that take place after the interaction with O3-biomolecules; in this case, organic peroxides, H2O2, ozonides, aldehydes, and other oxidation products generated in adequate and controlled quantities activate endogenous response mechanisms to the stress, managing to rebalance the redox environment that had been altered by the underlying pathology. While the initial mechanism shows the short-term effects of O3, this second mechanism requires time, which is why the application of a therapeutic cycle is required with several stimuli to achieve most of the effects of O3 [1,4].
Autofluorescence as a Parameter to Study Pharmaceutical Materials
Published in Victoria Vladimirovna Roshchina, Fluorescence of Living Plant Cells for Phytomedicine Preparations, 2020
Victoria Vladimirovna Roshchina
Among external factors influencing autofluorescence are UV radiation, ionizing radiation, high doses of tropospheric ozone, microbial invasion, and temperature (Roshchina V.V. and Roshchina V.D. 2003; Roshchina 2008, 2014). Light may be an important factor for medical plant cultivation. For example, the influence of sunshine hours on azulene synthesis in Matricaria chamomilla L. has been shown to be greater than that of soil alkalinity (Singh et al. 2011). The effects of ionizing and gamma irradiations on plant cell autofluorescence are known only from the few experiments on pollen (Roshchina et al. 1998b). Light quality and intensity, moistening, pH, and metals, as well as ozone and its derivatives, both free radicals and peroxides/ozonides, influence autofluorescence (Figure 2.8). This is described in detail in earlier publications: Roshchina et al. 1998a; Roshchina and Roshchina 2003; Roshchina 2008). Here, attention has been paid mainly to examples of medicinal plants.
Inorganic Chemical Pollutants
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
Also, ozone can generate new antigenic species and might react with susceptible subgroups in proteins and other cellular components, to modify their structural and antigenic characteristics. Autoimmune reactions after ozone may explain some of the high incidences of autoantibodies in a subgroup of chemically sensitive. Ozone attacks polyunsaturated fatty acids such as in lipid membranes and sulfhydryl groups of proteins (especially enzymes), free amino acids (e.g., cysteines), and GSH.99 It depletes the sulfhydryl content of the lung and cross-links the bases in DNA. It oxidized aromatic amino acids, especially tyrosine and phenylalanine, via their unsaturated rings.99 Ozone breaks down products into toxic ozonides, which also causes tissue damage, especially to the phospholipids of the cell membranes.100 Ozone can damage cytochrome enzymes of the pulmonary mixed-function oxidase (MFO) systems, resulting in increased chemical sensitivity.
Lung macrophages: current understanding of their roles in Ozone-induced lung diseases
Published in Critical Reviews in Toxicology, 2020
While the ELF layer serves to protect the mucosal surfaces of the respiratory tract from inhaled agents, molecular interactions between O3 and constituents of the ELF layer result in the generation of harmful ozonation products. Studies employing radioactive oxygen (18O) labeled O3 revealed a higher concentration of 18O in the ELF suggesting its incorporation into ELF biomolecules (Hatch et al. 1994). The incorporation of O3 into the unsaturated carbon backbone of ELF constituents, including phospholipids, cholesterol, epoxy cholesterol, proteins, and hyaluronic acids (HA), leads to a rapid drop in its levels within the ELF layer before it reaches the epithelial cells (Johnson 1980; Gordon et al. 1981; Sharman and Mudd 1981; Friedman et al. 1985; Madden et al. 1987). Through the Criegee reaction, ozonation of unsaturated fatty acids yields aldehydes, such as hexanal, nonanal, heptanal, and carbonyl oxide. These aldehydes have been shown to be elevated in the BALF of O3-exposed humans and rats (Pryor et al. 1996; Frampton et al. 1999a, 1999b). Among these, carbonyl oxide, being a reactive species, further combines either with aldehydes to form ozonide (incorporation of O3 in carbon–carbon chain) or with water to form hydroxy hydroperoxide in aqueous environments (Santrock et al. 1992).
The effect of medical ozone therapy in addition to ovarian detorsion in ischemia reperfusion model
Published in Journal of Obstetrics and Gynaecology, 2022
Sema Süzen Çaypınar, Sema Karakaş, Cihan Kaya, Damlanur Sakız, Salim Sezer, Murat Ekin
Ozone is triatomic oxygen (O3) which reacts with organic compounds containing double bonds (i.e. polyunsaturated fatty acids), and it acts with ozonides. The ozonides are immediately transformed into stable hydroperoxides during increased pH levels as they occur in IR conditions (Smith et al. 2017; Di Mauro et al. 2019). Medical ozone has an antioxidant effect, and its IR protective effect has been shown in many studies (Zamora et al. 2005). Despite all of the investigations, there is still no approved treatment modality that can be adopted with negligible side effects as an additional treatment with ovarian detorsion.