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Modified and Advanced Injection Techniques
Published in Yates Yen-Yu Chao, Sebastian Cotofana, Anand V Chytra, Nicholas Moellhoff, Zeenit Sheikh, Adapting Dermal Fillers in Clinical Practice, 2022
Yates Yen-Yu Chao, Sebastian Cotofana, Nicholas Moellhoff
Emerging in the 1950s, the practice of multiple superficial microinjections of various substances was the beginning of so-called mesotherapy. Though popular in some areas of Europe and South America, this kind of treatment was well accepted more widely because of the lack of clinical and scientific evidence. With the fast growth of injectable medicine in recent decades, more and more studies on the effect of mesotherapy have been conducted. Some of them also used injectable fillers, while the ingredients can be commercial injectable fillers alone or mixed with vitamins, drugs, etc. Different studies reported efficacy in pain control, hair growth, fat reduction, and skin enhancement. Some controversies remain about adverse events and the ingredients used for injection.
Role of Naturopathy in Pain Management
Published in Mark V. Boswell, B. Eliot Cole, Weiner's Pain Management, 2005
The basic premise of mesotherapy is that solutions injected intracutaneously remain in the injected area longer because they are slower to be cleared by general circulation than a deeper injection. Further, it is felt that the injected solutions continue to penetrate the deeper tissues. Kaplan (1985) injected calcitonin marked with a radioisotope and found upon serial scans that the more superficial the injections, the longer the solution remained in the area. LeCoz and DuPont (1993) conducted an experiment on patients scheduled to undergo arthroscopic surgery of the knee. The subjects were divided into three groups. The first group received intraepidermic papules of a diluted NSAID, the second group received injections of the same amount of the same solution using 4-mm needles, and the third group similarly received deep intramuscular injections. At hours 1 and 3 post-injection, venous blood draws were performed to determine serum levels of the NSAID. It was found that uniformly, the shallower the injection, the less of the substance was found in venous circulation at both 1 and 3 hours post-injection. During arthroscopy, synovial biopsies were performed, and all groups were found to have NSAID present, although levels were not determined (LeCoz and Dupont, 1983). Mesotherapy, therefore, appears to be a novel technique to administer medicines where the skin acts as a natural time-release system.
Systematic review of mesotherapy: a novel avenue for the treatment of hair loss
Published in Journal of Dermatological Treatment, 2023
Aditya K. Gupta, Shruthi Polla Ravi, Tong Wang, Mesbah Talukder, Michela Starace, Bianca Maria Piraccini
Mesotherapy is a method of intradermal administration of drugs and bioactive substances with the potential of treating hair loss disorders such as PHL and TE. Several studies have shown statistically significant improvements in hair growth after mesotherapy injections utilizing various therapeutic agents and homoeopathic solutions. The use of lower drug doses, localized administration, and lower frequency of injections are factors that can improve the utility of mesotherapy. However, mesotherapy is currently not approved by the U.S. FDA or Health Canada, and given the reports of serious adverse effects observed after mesotherapy sessions with some agents, it is advised to proceed with caution when using this empirical treatment. To reduce the possible development of allergic reactions to the therapeutic agents or the preparations being injected, pretreatment allergy testing should be considered when appropriate and clinically indicated. Currently, no standardized treatment regimen exists for mesotherapy, which necessitates further large-scale, controlled clinical trials to optimize its efficacy and safety profile.
Effect of mesotherapy with nanochip in the treatment of facial rejuvenation
Published in Journal of Cosmetic and Laser Therapy, 2020
Lingling Hu, Kejia Zhao, Wei Min Song
The adverse effects of environmental changes and aging on the skin gradually appear, especially the exposed parts of the face. These changes are characterized by a number of objective physical indicators, including skin dryness, laxity and poor elasticity, color and surface irregularity, formation of pronounced skin markings, and wrinkles of different intensity. In recent years, there has been an increasing emphasis on minimally invasive treatments and techniques designed to treat volume loss, wrinkles, and skin photo-damage. Mesotherapy is defined as a minimally invasive cosmetic medical treatment, which consists of multiple superficial injections of a mixture of various ingredients (1). It is a new simple method of drug delivery (2), however, intradermal injection with the use of a 0.3 × 4 mm/30 G needle or commercial device (called the mesogun) tends to be regarded as the actual mesotherapy. However, these methods have not been approved by the Food and Drug Administration. Therefore, in this study, we used nanochips as an appropriate technique for delivering the drug or ingredients to the target tissue such as the skin, and to observe the clinical effect of mesotherapy with nanochip for facial rejuvenation.
Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Parisa Nasrollahi, Khosro Khajeh, Elnaz Tamjid, Mohammad Taleb, Masoud Soleimani, Guangjun Nie
Obesity has become a worldwide major public health problem. Although some people are doing a lot of exercise and strict diet regimens, but localized fat stays in some parts of their body [1]. Mesotherapy is an efficient drug delivery method to avoid systemic adverse effects. Formulations containing phosphatidylcholine (PC) and sodium deoxycholate (NaDC) have been used in the mesotherapy and NaDC is the active component in this formulation and causes non-specific lysis of cell membranes [2]. NaDC is a type of bile acids, composed of an amphipathic steroid skeleton, with a hydrophilic alpha side, and hydrophobic beta side [3]. Some researchers have sought to use doxycolic acid and ursodeoxycholic acid, as a therapeutic agent with anti-inflammatory, antiviral, anti-cancer, and immune-stimulating properties [4,5]. Subcutaneous injections of NaDC have also shown to reduce size of human lipoma and treat “buffalo hump” in patients infected with human immunodeficiency virus (HIV) [6,7]. Injecting NaDC leads to degrading fat cells via a cytolytic mechanism and skin tightening [8], but may cause necrosis of surrounding fat tissue, such as skin, muscles, nerves, and blood vessels in body [9–11]. The sustained and local release of NaDC in fatty tissues might lead to reduction of aggressiveness, improvement of efficiency, and increase in selectivity of fat cells.