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Metallopharmaceuticals
Published in Varma H. Rambaran, Nalini K. Singh, Alternative Medicines for Diabetes Management, 2023
Varma H. Rambaran, Nalini K. Singh
The element vanadium is classified as a first-row transition metal, with the symbol V and atomic number 23 (Figure 4.2). It has a low natural abundance and can exist in several oxidation states. However, once artificially isolated, the subsequent formation of an oxide layer (passivation) somewhat stabilizes the free metal against further reactivity and allows for its use in various applications.
Inhalation Toxicity of Metal Particles and Vapors
Published in Jacob Loke, Pathophysiology and Treatment of Inhalation Injuries, 2020
Industrial exposures are generally described as acute episodes with relapses and sometimes chronic coughing and chronic bronchitis as sequelae. Symptoms, generally upper and lower respiratory tract irritation, do not appear until after repeated exposure to vanadium compounds for a few days or a week, which may indicate development of delayed hypersensitivity. Respiratory symptoms are disabling (Stokinger, 1981).
Antidiabetic Potential of Medicinal Mushrooms
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Vivek K. Chaturvedi, Sushil K. Dubey, M.P. Singh
C. comatus has bioactivites, such as antidiabetic, antioxidant, and antimutagenic. The absorbing ability of trace elements is a great advantage for C. comatus. C. comatus shows hypoglycemic effect with vanadium. Most of the studies have suggested that vanadium has the ability to imitate insulin and showed good antidiabetic effects.27,78,91 When C. cosmatus are treated with vanadium, it showed significant positive results on diabetic mouse model and is confirmed as a hypoglycemic medicine.30,31,76,108
Protective effect of indomethacin on vanadium-induced adrenocortical and testicular damages in rat
Published in Toxicology Mechanisms and Methods, 2022
Rituparna Ghosh, Samudra Prosad Banik
Vanadium is a persistent and bioaccumulative environmental toxicant. Previous studies had highlighted the toxicity of vanadium including reproductive toxicity (Ghosh and Banik 2016). The specific mechanisms by which the metal exerts its effects have also been mostly delineated (Ghosh et al. 2020). Vanadium derivatives act as generator of free radicals, that impair testicular functions, spermatogenesis and sperm maturation in rats. Moreover, a strong correlation exists between vanadate-induced reproductive toxicity and increase in lipid peroxidation (Chandra et al. 2007a, 2007b, 2007c; 2010). Several lines of evidences also indicate that stimulation of prostaglandin release is one of the chief mechanisms of vanadate action (Plass et al. 1992). Evidences from the present studies also confirmed that vanadate induces testicular toxicity in rats by stimulating prostaglandin release.
The effects of a new antidiabetic glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in high-fat diet of streptozotocin-induced diabetic rats
Published in Archives of Physiology and Biochemistry, 2022
Gholamreza Komeili, Fatemeh Ghasemi, Ali Reza Rezvani, Khaled Ghasemi, Farzaneh Khadem Sameni, Mohammad Hashemi
Over the years, vanadium compounds have received special attention because of their usage as therapeutic agents in the control of diabetes mellitus (Trevino et al. 2019). Vanadium compounds are commonly observed to have insulin-enhancing properties and anti-diabetic effects both in vivo and in vitro (Li et al. 2009, Xie et al. 2014). Crans et al. (2003) investigated the impact of (4-hydroxypyridine-2,6-dicarboxylato)oxovanadate (V) on STZ-induced diabetic rats and have found that this complex lowers the diabetic hyperglycemia. The vanadium (V) complex of dipicolinate, [VO2dipic]-, was found to have insulin-like properties (Crans 2000). It has been reported that methyl and iodo derivatives of bis(picolinato) oxovanadium(IV), have insulin-like properties (Fujimoto et al. 1997, Sakurai et al. 1995). Niu et al. (2007) have found that administration of Bis(α-furancarboxylato)oxovanadium(IV) significantly improved hyperglycemia, glucose intolerance and hyperinsulinemia, as well as increased insulin sensitivity index in the fat-fed/streptozotocin-diabetic rats (a type 2-like diabetic animal model). They observed that the complex activated glucokinase, increased hepatic glycogen content and significantly decreased the expression level of phosphoenolpyruvate carboxykinase (PEPCK) in the liver and kidney of the diabetic rats, which contributed to augmentation of hepatic glucose disposal and maintenance of blood glucose homeostasis.
The impact of concomitant administration of vanadium and insulin on endothelial dysfunction markers (PAI-1 and ET-1) in type 1 diabetic rats
Published in Archives of Physiology and Biochemistry, 2021
M. D. Morsy, I. Bin-Jaliah, S. O. Bashir, A. Shatoor, M. A. Haidara
Several researchers reported that the endothelial complications in diabetes occurs in spite of proper glycaemic control. Several attempts try to find a supportive therapeutic agent to insulin, especially in type 1 diabetes to avoid endothelial vascular complications. Vanadium is a trance element that is widely distributed in nature and present in the animals and human at a minimal concentration (Shurtz-Swirski et al.2001). Metavanadate is the most common form of vanadium in the extracellular fluids, whereas, the most prevalent intracellular is the vanadyl (Panchal et al.2017). Its oral administration has been reported to improve DM type-1 and -2 in humans and also acts in synergism with insulin to protect against the development of diabetic complications (Wu et al.2012). Glucose intolerance was completely improved, hepatic triacylglycerol (TG) content decreased, width of subcutaneous fat decreased and body weight decreased by 20% in fatty Zucker rats treated with an oxovanadium (Metelo et al.2012). So, the aim of the present study was to investigate the preventive role of concomitant administration of insulin and vanadium on oxidative stress and endothelial dysfunction makers in type one diabetes mellitus.