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Potential of Fenugreek in Management of Kidney and Lung Disorders
Published in Dilip Ghosh, Prasad Thakurdesai, Fenugreek, 2022
Amit D. Kandhare, Anwesha A. Mukherjee-Kandhare, Subhash L. Bodhankar
Fenugreek (Trigonella foenum graecum) has a long history of use since ancient times for its culinary and medicinal potential. It is native to Western Asia, the Mediterranean region, and southern Europe; its seed is widely used for cooking and traditionally used to treat various maladies, including diabetes, inflammation, and hyperlipidemia (Murakami et al. 2000; Patil, Niphadkar, and Bapat 1997). An array of investigators documented its antioxidant and antiinflammatory benefits during various experimental and clinical studies (Chevassus et al. 2009; Chevassus et al. 2010; Emtiazy et al. 2018; Khan, Negi, and Kumar 2018). Fenugreek seed contains many phytoconstituents, including alkaloid (trigonelline), furostanol and flavonol glycosides, and steroidal saponins. Researchers have established a key role of fenugreek phytoconstituents in managing various maladies (Wani and Kumar 2018; Zameer et al. 2018).
Gestational Weight Gain and Postpartum Obesity
Published in Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak, Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Trigonella foenum-graecum, commonly referred to as fenugreek, is an erect annual herb from the soy family that originated from India and North Africa. [46, 47] This has been used as a galactogogue historically, the reason being that it contains significant levels of phytoestrogens. Diosgenin is a phytoestrogen that is believed to be responsible for an increase in milk flow. [42] Habitually, fenugreek tea is prepared by brewing the seeds in boiling water for 20 minutes and it is consumed. This ingredient is also an excellent weight loss supplement, as fenugreek seeds contain saponins and alkaloids as well as soluble dietary fibers, which help increase the feeling of satiety, reducing the wish to eat throughout the day. [46] These seeds have also demonstrated hypoglycemic and hypolipidemic effects in multiple preclinical and clinical studies, as summarized by Parveen Kumar and Uma Bhandari in the review titled “Common medicinal plants with ant obesity potential: A special emphasis on fenugreek.” [48]
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Trigonella foenum-graecum, commonly known as fenugreek, is an annual plant in the family Fabaceae. It has a long history of human use, both as medicine and foodstuff, and is thought to have first been cultivated as long as 6,000 years ago. Consumption of seeds, sprouts, and leaves in many Near Eastern and Mediterranean cuisines speaks to its relative safety. The leaves and seeds have been used to prepare extracts or powders for medicinal use in Chinese, Ayurvedic, Greek, Roman, and European herbal traditions. It has been used as a general tonic, and for conditions as varied as used as weakness, edema, failure of lactation, indigestion, flatulence, and baldness.1 Modern studies suggest potential for treatment of diabetes, Metabolic Syndrome, and MDD.
Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis
Published in Drug and Chemical Toxicology, 2022
Vadivel Dinesh Babu, Anandasadagopan Suresh Kumar, Ganapasam Sudhandiran
Phytochemicals from herbs have gained enormous attention toward treatment as chemotherapeutic agents. Among these phytochemicals Diosgenin, a bioactive steroidal triterpene sapogenin present in the species of Trigonella foenum graecum and Dioscorea villosa, has greatly influenced the ‘drug discovery’ realm as it is a main precursor in progesterone synthesis. Pharmacological features such as anti-inflammatory, androgenic and contraceptive properties are observed in the seeds and leaves of fenugreek (Premanath et al.2011). Over the past few years, growing body of evidences suggests that diosgenin possesses anti-inflammatory (Gao et al.2013), anti-atherosclerosis (Liu et al.2012), hypoglycemic and anti-cancer properties (Mao et al.2012, He et al.2014, Jiang et al.2016). Accumulating evidences indicate that diosgenin inhibits hepatic and renal fibrosis (Wang et al.2014, Xie et al.2015). However, there is lack of evidence against BLM induced pulmonary fibrosis which mimics human fibrosis. Therefore, in the present study, the fibro-protective effect of diosgenin against experimental pulmonary fibrosis in in vivo and in vitro is studied.
Differences in male climacteric symptoms with aging among rotating night shift workers
Published in The Aging Male, 2020
Sachiko Kubo, Toshiyuki Yasui, Yukie Matsuura, Masahito Tomotake
The proportion of men in the present study who reported sexual symptoms was small, but the proportion increased with advance of age. In addition, there were significant differences in AMS scores for sexual symptoms between men in their 30 s and those in their 40 s and between men in their 40 s and those in their 50 s. Kobayashi et al. [22] reported that mean sexual AMS scores were 12.9 in men who received medical examinations and 15.6 in men with male climacteric symptoms. The mean AMS score for sexual symptom in the present study was 7.5, and this level was lower than that in the previous study [22]. Haider et al. [25] reported that AMS scores decreased in a testosterone-treated group, suggesting that testosterone therapy is effective for improvement of sexual function and quality of life. In addition, Rao et al. [26] reported that treatment with Trigonella foenum-graecum seed extract improved sexual function in middle-aged and older men. Medical treatment should be considered for night shift workers with sexual symptoms.
Attitude towards sexuality and sexual behaviors among men with heart rhythm disorders
Published in The Aging Male, 2020
Rafal Mlynarski, Agnieszka Mlynarska, Krzysztof S. Golba
Decreased sexual frequency and loss of libido can also predict a higher 10-year cardiovascular risk, what was documented by Ho et al in hypogonadal men [26]. The incidence of erectile dysfunction increases with age and depends on many health and psychosocial factors. The conditions and states that are associated with erectile dysfunction include diabetes, hypertension, coronary heart disease, obesity, difficult micturition, low socioeconomic status, sedentary lifestyle, smoking, depression, subjectively reported premature ejaculation, low libido, and irregular intercourse [27]. The lowest prevalence of erectile dysfunction is observed in men who do not have chronic conditions and live a healthy lifestyle. Erectile dysfunction can be seen as both a risk factor and a clinical manifestation of the progression of atherosclerosis [28]. We also believe that substances like Testofen, a specialized Trigonella foenum-graecum seed extract can support sexual function in aging males [29]. Rao et al. in a double-blind, randomized, placebo-controlled trial examined influence of Trigonella foenum-graecum seed in 120 healthy men aged between 43 and 70 years of age. Authors concluded that Testofen is a safe and effective treatment for reducing symptoms of possible androgen deficiency, improves sexual function and increases serum testosterone in healthy middle-aged and older men. Unfortunately, additional research in patients with cardiac arrythmias is necessary to support our thesis.