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Scutellaria Species and Cancer Research
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Samantha H. Sherman, Lani Irvin, Prahlad Parajuli, Nirmal Joshee
Sho-saiko-to is a mixture of seven herbs, including S barbata, that has been traditionally used in Japan and China for the treatment of chronic hepatitis and liver fibrosis (Shimizu, 2000). Sho-saiko-to has been used for the treatment of liver cancer. A clinical study has been conducted to study the efficacy of Sho-saiko-to following removal of liver cancer by embolization in patients with surgically unresectable liver cancer; however, the result has not been published (DeMatteo, 2003).
Anti-Hepatofibrotic Effect of Xiao-Chaihu-Tang (Sho-Saiko-To)
Published in Sheng-Li Pan, Bupleurum Species, 2006
Chinese herbal medicines have now attracted the attention of practitioners of Western medicine, and are being manufactured in uniform quality and in sufficient quantities for utilization as hospital drugs in Japan. Among these herbal medicines, Xiao-Chaihu-Tang (Sho-saiko-to), which has been used in the treatment of pyretic diseases in China, is an officially approved prescription drug in Japan. As the most commonly administered herbal medicine, Sho-saiko-to is used for the treatment of patients with chronic liver disease, especially those with chronic hepatitis C virus (HCV) infection, chronic hepatitis C (Hirayama et al., 1989; Tajiri et al., 1991), and cirrhosis (Oka et al., 1995). The root of Bupleurum falactum is one of the chief components of Japanese Sho-saiko-to. The usual daily dose of Sho-saiko-to is 7.5 g,, which is administered orally in three equal doses. The 7.5 g of Sho-saiko-to contains 4.5 g of dried Sho-saiko-to extract, which is prepared from boiling water extracts of seven herbs: 7.0 g of Bupleurum root, 5.0 g of Pinellia tuber, 3.0 g of Scutellaria root, 3.0 g of jujube fruit, 3.0 g of ginseng root, 2.0 g of glycyrrhiza root, and 1.0 g of ginger rhizome.
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
Published in Pharmaceutical Biology, 2021
Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang, Jing Guo
There is a saying in TCM, “Bupleuri Radix consumes liver Yin,” which means that Bupleuri Radix can harm the liver Yin if used too much or for a long time. However, because the toxicity of Bupleuri Radix was not clearly recorded in the ancient Chinese medical literature, it did not arouse people's attention. Bupleuri Radix has long been regarded as an effective and non-toxic herb, and its toxicity is even not recorded in the Chinese pharmacopoeia. It was not until the clinical reports of drug toxicity damage caused by Bupleuri Radix and its compound preparations appeared successively in modern clinical application, especially the Sho-saiko-to poisoning incident in Japan that extensive attention and research on the toxicity of Bupleuri Radix was aroused. In Japan, Bupleuri Radix and its compound preparations are the hottest aspect in toxicity research of Kampo medicines (Ikegami et al. 2003). Modern studies have shown that SSs are not only the main effective components, but also the main toxic components of Bupleuri Radix (Lv et al. 2009; Huang and Sun 2010), therefore, it is necessary to rationally apply SSD in the context of in-depth understanding of its toxic effects. The toxicological effects of SSD reported presently were mainly hepatotoxicity, neurotoxicity, haemolysis and cardiotoxicity, and the mechanisms of these toxicities are summarised in Table 3.