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Special Considerations for Men's Health
Published in Gia Merlo, Kathy Berra, Lifestyle Nursing, 2023
Red ginseng has limited evidence but has been demonstrated to improve erectile function rates compared to placebo. The red ginseng dosage was 0.5 to 2.0 g daily. Some negative symptoms associated with red ginseng were headache, insomnia, gastric upset, and constipation (Jang et al., 2008).
Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Kumar Anand, Subhabrata Ray, Md. Adil Shaharyar, Mahfoozur Rahman, Rudranil Bhowmik, Sanmoy Karmakar, Monalisha Sen Gupta
Panax ginseng is also an important source of drug from herbal arena used for CVDs mainly HTN, myocardial ischemia and dyslipidemia. Ginseng is one of the older and traditional drugs used from natural sources. Part of the ginseng responsible for the drug action is known as ginsenoside. As far as the pharmacological actions are concerned as there are innumerable types of ginsenoside identified, it may have various pharmacological actions involve in the therapy. About 40 ginsenosides has been identified till 2012 depending on the method of separation and analysis (Fuzzati, 2004). In a proof of concept study, it has been found that the Korean red ginseng increases blood pressure (BP) in case of low BP while it works as an antihypertensive in the condition of higher BP (Jeon et al., 2000).
Herbal Therapies
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
H. Shahrul, M. L. Tan, A. H. Auni, S. R. Nur, S. M. N. Nurul
Ginseng is a well-known traditional herbal medicine due to its numerous benefits. Although ginseng exhibits a variety of physiological and pharmacological activities, ginseng saponin (or ginsenoside) has no specific receptor. Therefore, ginseng saponin alone may not explain all of ginseng’s actions (Nah et al., 2007). Recent studies found presence of unique form of LPAs, designated gintonin. It was co-isolated with ginseng proteins such as ginseng major latex-like protein 151 and ginseng major storage protein. The complex of LPAs and ginseng proteins could be involved in the physiological and pharmacological actions of LPAs as the free form of LPAs are labile to hydrolysis by lipid phosphate phosphatase (Salous et al., 2013). The protein component might protect LPAs from hydrolysis. They may also play roles in storage and transportion of LPAs to receptors at target organs. The most abundant LPA species in gintonin are LPA C18:2 > LPA C16:0 > LPA C18:1. The study also indicated that ginseng contained high LPAs content, where it was 10-fold than the amount present in corydalis tuber and other foodstuff.
Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer
Published in Nutrition and Cancer, 2023
Maliheh Hamidian, Farzaneh Foroughinia, Mahboubeh Yousefi, Shirin Haghighat, Elham Haem
Complementary/alternative medicine has dated back to thousands of years with a high prevalence of use amongst breast cancer patients in the past decade for overcoming poor HRQOL induced by chemotherapy (11). Ginseng root (Panax ginseng C.A. Meyer, Araliaceae; hereafter “PG”) is one of the most popular herbal medicines as an “adaptogen in many countries for thousands of years (12). This popular herbal medicine reduces chemo-resistance, induces apoptosis, and possesses tumor-inhibiting properties through its anti-proliferative, anti-inflammatory, and antioxidant effects which make it as a potential chemo preventive and chemotherapeutic agent in combination with conventional chemotherapeutic regimens (13, 14). According to In Vivo human studies, regular ginseng use improves both overall and disease-free survival in breast cancer survivors (15). Moreover, ginseng has vitality-enhancing properties and anxiolytic-like effects that improves mood by controlling fatigue, mitigates pain and headache, reduces physical, chemical, and biological stress, and enhances cognitive functioning and performance status (16, 17).
The transnational move of interdisciplinarity: Ginseng and the beginning of neuroscience in South Korea, 1970–1990s
Published in Journal of the History of the Neurosciences, 2022
Studies on herbs—particularly ginseng—received much attention from the government in the 1970s, as herbs had become promising candidates for export. Under the authoritarian regime of Chung-Hee Park (1963–1979), increasing exports was touted as “the only way for Korea to survive” (Kim 2017; Lee et al. 2005; The Editorial Board 1997). The government was committed to finding and “exporting whatever [we] can sell” (Park 2014). Textiles, wigs, and plywood were the most popular exports in the 1960s. The government celebrated the increase of export from U.S. $25 million in 1956 to U.S. $100 million in 1964, designating November 30 of that year as the First Memorial Day of Export. In this milieu, from the mid-1960s, ginseng was spotlighted as an important export item to be developed. There were several types of ginseng: for example, American ginseng (Panax quinquefolius), South China ginseng (Panax notoginseng), and Korean ginseng (Panax ginseng), depending on cultivation areas. It was therefore important for South Korea to differentiate its ginseng from others and to promote Korean ginseng’s distinctive effects and strengths (Park et al. 2014, 126). To this end, the government invested in various research projects to increase the competitiveness of Korean ginseng as an export.
Ginsenosides Rd monomer inhibits proinflammatory cytokines production and alleviates DSS-colitis by NF-κB and P38MAPK pathways in mice
Published in Immunopharmacology and Immunotoxicology, 2022
Bo Qu, Ting Cao, Miao Wang, Shuang Wang, Wanying Li, Hui Li
Ginseng extract ginsenosides Rd was purchased from Nanjing Spring and Autumn Biological Engineering company (Nanjing, China). Dextran sulfate sodium salt (DSS, molecular weight 36–50 KDa) and Sodium thioglycolate were obtained from Eugene Biological company (Shanghai, China). LPS was purchased from Sigma-Aldrich (St. Louis, MO, USA). ELISA kits were purchased from eBioscience (San Diego, CA, USA). Antibodies for TNF-α, IL-6, IL-17A, IL-12/23p40 were manufactured by Santa Cruz Biotechnology (Santa Cruz, CA, USA) and enhanced chemiluminescence. Western blotting detection reagents were purchased from Beyotime Bioengineering Institute (Shanghai, China), rabbit radish peroxidase-conjugated anti-mouse antibody (Santa Cruz, 1:1000), and anti-rabbit antibody (Santa Cruz, 1:1000). All other materials were commercially available, and all other compounds were from Sigma unless stated.