Explore chapters and articles related to this topic
Prostatic Hypertrophy/Benign Prostatic Hypertrophy (BPH)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Pumpkin seed oil (320 mg/day) improved symptoms of BPH for all patients receiving treatment with it over 12 months in comparison with a placebo. One reason may be that pumpkin seed oil is high in zinc, which is critical to normal prostate function.10
Role of Nutraceuticals in Prevention of Nonalcoholic Fatty Liver
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Plant- and Marine-Based Phytochemicals for Human Health, 2018
Pumpkin seed oil and stabilized rice bran oil afford hepatoprotection against NASH in rat model. The mechanism of action involved antioxi- dant and anti-inflammatory activity along with the reduction of liver fat and improvement of hypercholesterolemia. Both oils improved liver histo- pathological changes but pumpkin seed oil was superior in this respect where it reversed all histopathological abnormalities in liver tissue which became comparable to normal.9 The bioactivity of both oils could be related to the presence of bioactive constituents. It has been reported that rice bran oil contains stigmasterol, campesterol, beta-sitosterol, and trit- erpenoid compounds (alpha and beta-amyrin). Beta-carotene and alpha, gamma, and delta tocopherols and tocotrienols were also identified in rice bran oil. Gamma-oryzanol, policosanol (long-chain primary fatty alcohol), and oleic and linoleic fatty acids are among the important phyto- chemicals and nutrients, which are present in rice bran oil, and possess health benefits.7 Pumpkin seed oil has been reported to contain alpha and delta tocopherols, phytosterols, beta-carotene, phenolic compounds, oleic acid as monounsaturated fatty acid, and linoleic acid which is omega-6 fatty acid.11, 55, 80, 85Nanoemulsion prepared from pumpkin seed oil showed superior effect in preventing the progression of fatty liver compared to the native form of the original oil. The effect of the nanoemulsion was mani- fested in a very low dose with a sustainable action due to the increased absorption and bioavailability.10
Formulation development and accelerated stability testing of a novel sunscreen cream for ultraviolet radiation protection in high altitude areas
Published in Drug Development and Industrial Pharmacy, 2019
Nilutpal Sharma Bora, Bhaskar Mazumder, Pompy Patowary, Sumit Kishor, Yangchen Doma Bhutia, Pronobesh Chattopadhyay, Sanjai Kumar Dwivedi
Melatonin (N-acetyl-5-methoxytryptamine), an endogenous hormone secreted primarily by the pineal gland in the human body, has very high antioxidant and anticarcinogenic properties [6]. It has been found to elicit superior activities in cases of treating human cancers, X-ray irradiation-induced lipid peroxidation, UV induced erythema and dose-dependent immunomodulation [12,13]. Pumpkin seed oil (PSO), which is a popular edible oil; has also made its mark as a nutraceutical which contains a high amount of antioxidant vitamins, phytosterols, and proteins. It possesses a lipid profile which consists of 43–53% of linoleic acid, along with tocopherols, and phenolics. L-ascorbic acid, the most abundant intracellular and extracellular aqueous-phase antioxidant, is also present in PSO as a result of which even small quantities of PSO can benefit the skin very effectively [14].
Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF-κB suppression
Published in Immunopharmacology and Immunotoxicology, 2019
Nilutpal Sharma Bora, Bhaskar Mazumder, Santa Mandal, Yangchen D. Bhutia, Sanghita Das, Sanjeev Karmakar, Pronobesh Chattopadhyay, Sanjai K. Dwivedi
The aim of the present study was to determine the protective effects of a cosmeceutical sunscreen formulation against UV induced psoriasis-like symptoms. The formulation tested herein is a first of its kind and has successfully passed the preclinical toxicity profiling which has been reported earlier [12]. The inclusion of pumpkin seed oil and melatonin is expected to provide a boost to the antioxidant potential of the formulation and exert a synergistic sun protective effect. Table 1, shows the composition of the formulations, namely test, placebo nad standard. As seen, the test formulation is comprised of the test formulation contains one US FDA approved inorganic UV filter, titanium dioxide; three organic US FDA approved UV filters, namely benzophenone-3, ethylhexyl methoxycinnamate, and butyl methoxydibenzoylmethane and as active ingredients. The antioxidant cocktail of melatonin (N-acetyl-5-methoxytryptamine) and pumpkin seed oil along with these UV filters is aimed at countering the generation of ROS and its unwanted effects. The pineal hormone melatonin has been found to be potent antioxidant, immunomodulator, and dose-dependent sunscreen whereas pumpkin seed oil has been found to contain 43–53% of linoleic acid and two classes of antioxidant compounds, namely tocopherols and phenolics, which when used even in small proportions in topical formulations can have significant beneficial properties [19–21].
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery
Published in Pharmaceutical Development and Technology, 2023
Rana Abu-Huwaij, Adian Alkarawi, Dima Salman, Furqan Alkarawi
Androgenetic alopecia is a genetic disorder caused by an overreaction to androgens. This disorder, which affects up to 50% of both males and females, is characterized by gradual loss of hair at any point after puberty (Ho et al. 2022). Pumpkin seed oil (Cucurbita pepo L.) is mostly composed of saturated and unsaturated fatty acids (Hajhashemi et al. 2019). Pumpkin seed oil-loaded niosome is prepared using tween 20 surfactants and cholesterol, the studies showed better skin permeation, reduce in hair loss by 44.42% and the serum is not irritant to the human scalp (Teeranachaideekul et al. 2022).