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Prostatic Hypertrophy/Benign Prostatic Hypertrophy (BPH)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Pumpkin seed oil (320 mg/day) improved symptoms of BPH for all patients receiving treatment with it over 12 months in comparison with a placebo. One reason may be that pumpkin seed oil is high in zinc, which is critical to normal prostate function.10
Macronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
On a worldwide basis, plant protein foods contribute over 60% of the per capita supply of protein, on average (1). Plant sources of proteins include legumes (lucernes, peas, beans, lentils, lupines, soybeans, peanuts, tamarinds, etc.), nuts, seeds, and fruits. These vegetarian foods are high in protein with protein concentrations greater than 7% (1). Other seeds and nuts rich in proteins and amino acids are: kidney beans, white beans, chickpeas, cowpeas, lima beans, pigeon peas, lupines, wing beans, almonds, Brazil nuts, cashews, pecans, walnuts, pumpkin seeds, hemp seeds, sesame seeds, chia seeds, and sunflower seeds. Fruits rich in proteins and amino acids include avocado, jackfruit, banana, cherries, kiwi, orange, pomegranate, raspberries, peaches, nectarines, currants, and grapefruits. Plant foods have advantages over animal foods regarding the prevention of harmful chronic diseases such as cardiovascular diseases, cancer, and obesity thanks to their low saturated fats and cholesterol. Indeed, vegans can obtain all essential amino acids by eating a variety of plant proteins.
Mood and Food, Cravings, and Addiction
Published in Emily Crews Splane, Neil E. Rowland, Anaya Mitra, Psychology of Eating, 2019
Emily Crews Splane, Neil E. Rowland, Anaya Mitra
There could be other bioactive ingredients in chocolate that make it special. For example, chocolate contains significant amounts of riboflavin (vitamin B2), magnesium, and antioxidants, all of which enhance health. Perhaps deficiencies for these vitamins and minerals contribute to chocolate craving. For example, women tend to have increased cravings for chocolate when experiencing premenstrual syndrome, a time associated with reduced levels of magnesium (Bruinsma & Taren, 1999). However, many infrequently craved foods contain much higher amounts of magnesium (including barley, spinach, and pumpkin seeds). And riboflavin deficiency is an unlikely explanation for chocolate craving because riboflavin concentrations in chocolate are some 20-fold lower than they are in less preferred foods such as liver. So, despite some possible health benefits of chocolate, these are implausible as the basis for chocolate craving.
Development and optimization of a tamsulosin nanostructured lipid carrier loaded with saw palmetto oil and pumpkin seed oil for treatment of benign prostatic hyperplasia
Published in Drug Delivery, 2022
Rana B. Bakhaidar, Khaled M. Hosny, Imman M. Mahier, Waleed Y. Rizq, Awaji Y. Safhi, Deena M. Bukhary, Muhammad H. Sultan, Haitham A. Bukhary, Osama A. Madkhali, Fahad Y. Sabei
Pumpkin seed oil (PSO) belongs to the Cucurbitaceous family. It exhibits potent activity against nocturia and urinary incontinence and reduces the frequency of urination (Roehrborn et al., 2015). It was also found that the use of a hydroalcoholic extract of pumpkin seeds exhibited a protective effect against hyperplastic and cancerous cells, and the findings strengthened the antihyperplastic role of PSO (Leibbrand et al., 2019). Studies have also shown that PSO exhibited a protective effect against testosterone-induced prostate hyperplasia via the inhibition of 5-α-reductase (Vahlensieck et al., 2015). The chemical composition of PSO includes phytosterol, fatty acids (oleic acids, palmitic acid, linoleic acid), triterpene, and tocopherols (Nawirska-Olszańska et al., 2013). In the Caribbean region, P is used as a nutraceutical and dietary supplement, whereas in North India, Mexico, North America, Europe, and China, its use for bladder disease is gaining acceptance (Alhakamy et al., 2019). Thus, based on published reports, it was found that PSO could be an emerging treatment modality for the management and treatment of BPH.
Therapeutic effects of fluted pumpkin seeds on cadmium-induced testicular injury
Published in Toxin Reviews, 2022
Ogechukwu E. Ezim, Sunny O. Abarikwu
Fluted pumpkin “Telfaria occidentalis” is a tropical crop belonging to the Cucurbitaceae family. The leaf is widely consumed as a vegetable, while the seeds are used as soup condiments in the southern part of Nigeria. Fluted pumpkin seed (FPS) extract is useful as an immunomodulatory agent and has reproductive health effects along with therapeutic properties over a wide range of disease conditions (Fruhwirth and Hermetter 2007, Stevenson et al. 2007). Fluted pumpkin seeds have been shown to have protective effects on the testes of rats and other experimental mammalian animals under different pathologic situations. For example, FPS oil improves semen quality and sex hormone levels (e.g. testosterone and luteinizing hormone) and has a prophylactic effect against alcohol-induced testicular damage in rats (Akang et al. 2010). Other studies have also demonstrated that FPS can improve the secretory capacity of the testes and inhibit the induction of experimental andropause in rats (Ejike and Ezeanyika 2012). We also recently reported that FPS extracts protected young adult rats against atrazine-induced testicular damage (Abarikwu et al. 2020) and busulfan-induced testicular injury (Abarikwu et al. 2019).
Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries in adult mice
Published in Drug and Chemical Toxicology, 2022
S. O. Abarikwu, C. J. Mgbudom-Okah, C. L. Onuah, A. Ogunlaja
These findings support the potential effects of ethanolic extract of FPS in the recovery of spermatogenesis during chemotherapy and qualify FPS as a pro-drug candidate for helping to regain testicular functions after cancer therapy in humans. Overall, the present data indicate that: (1) FPS has the potential ability to recover spermatogenesis by mitigating the side-effect of busulfan; and (2) FPS could decrease busulfan-induced LCs atrophy thereby directly stimulating testosterone production required for germ cell development. Fluted pumpkin seeds could therefore find application at the clinical level to repair impaired testicular functions caused by anticancer agents.