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Curcumin Nanomedicine and Their Application in the Management of Disease
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Sadaf Jamal Gilani, Syed Sarim Imam, Mohammed Jafar, Sultan Alshehri, Mohamad Taleuzzaman, Mohammed Asadullah Jahangir
The research group formulated curcumin nanoemulsion to assess the in-vivo anti-inflammatory activity and arthritic activity using carrageenan-induced paw edema and FCA induced arthritic rat model. The optimized curcumin nanoemulsion with emu oil was converted into carbopol gel and their biological activities were measured. The curcumin formulation in combination with emu oil showed significant improvement in anti-inflammatory activity and arthritic scoring, paw volume, biochemical, molecular, radiological, and histological examinations (Jeengar et al., 2016). The formulation of curcumin loaded self-nano emulsifying drug delivery system (SNEDDS) has been prepared and evaluated. The optimized formulation comprised of ethyl oleate:tween 80:PEG 600 (50:40:10% w/w) with 11. 2-nm uniform droplets showed a significant increment of 3. 95 times in Cmax, and the curcumin bioavailability was enhanced by 194. 2%, compared to the curcumin suspension in water (Nazari et al., 2017).
Recent Cannabinoid Delivery Systems
Published in Betty Wedman-St Louis, Cannabis as Medicine, 2019
Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Daniela Gastaldi, Franco Dosio, Enrica Pessione
The use of cannabinoids, in combination with odorous volatile compounds and emu oil, has also been proposed as a method to improve the effectiveness of cannabinoid transdermal delivery to areas in the hypodermis [106].
Sensory Analysis Applied to Cosmetic Products
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Regina Lúcia F. de Noronha, Heather A.E. Benson, Vânia Rodrigues Leite-Silva
Parente et al. (2008) used a descriptive sensory analysis to characterize the sensory properties of four commonly used emollients: cyclomethicone (CM), dimethicone (DM), isopropyl myristate (IPM) and octyldodecanol (OD); and four emollients from ratite oil: emu oil (EO), nandu oil (NO), olein (glyceryl trioleate: O15) and estearin (E15). A trained sensory panel composed of 12 assessors evaluated 5 attributes (spreading difficulty during application, gloss and stickiness immediately after application, residue and oiliness immediately after application, and after 5 and 10 min) using a structured 10-point scale (0 = nil; 10 = high).
Combined Nutraceuticals: A Novel Approach to Colitis-Associated Colorectal Cancer?
Published in Nutrition and Cancer, 2019
Lauren C. Chartier, Gordon S. Howarth, Suzanne Mashtoub
Animal-derived oils have previously been investigated for their use in various inflammatory conditions. Oils derived from ratites (flightless birds) including the ostrich (Struthio camelus), rhea (Rhea americana), cassowary (Casuarius), and the Australian emu (Dromaius novaehollandiae) are of interest. Native Aboriginal people traditionally used Emu Oil topically to alleviate pain and promote wound healing due to the anti-inflammatory, skin-permeation, and antioxidant properties it possesses (28). Emu Oil is derived from subcutaneous and retroperitoneal Emu adipose tissue and comprises 98.8 and 98.0%, fatty acids respectively, Table 1. Sourced from Mashtoub (2017) (29) details the fatty acid composition of Emu Oil compared to other ratite oils and an olive oil control. The fatty acid fraction comprises oleic acid (omega-9; 42%), linoleic acid (omega-6; 21%), palmitic acid (21%), and lower levels of α-linolenic acid (omega-3; 1%) (28).
Drug discovery strategies for modulating oxidative stress in gastrointestinal disorders
Published in Expert Opinion on Drug Discovery, 2020
Taraneh Mousavi, Nastaran Hadizadeh, Shekoufeh Nikfar, Mohammad Abdollahi
Some animals are considered as an origin of antioxidants. Emu oil, with having a high level of polyunsaturated fatty acids (PUFAs), is extracted from the subcutaneous fat of Emu, a flightless bird. Either separate administration of Emu oil or in combination with Aloe leaf gel extract, Emu oil demonstrated great potential in enhancing OS and disease conditions in rat Crohn’s model [190]. Like Emu oil, fish oil is a valuable source of PUFAs which was reported to be able to return CAT, SOD, and MDA levels to the baseline, and significantly increase GR level, separately or in combination with mesalazine [191].
Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
Published in Nutrition and Cancer, 2022
Suzanne Mashtoub, Lauren C. Chartier, Debbie Trinder, Ian C. Lawrance, Gordon S. Howarth
AOM/DSS resulted in significant bodyweight loss throughout the trial (p < 0.05) compared with normal controls (Figure 1). In AOM/DSS mice, Emu Oil (160 µL) increased bodyweight compared with disease control mice (p < 0.05; Figure 1); and low volume Emu Oil (80 µL)-treated mice (p < 0.05; Figure 1). Furthermore, 80 µL of Emu Oil did not significantly attenuate bodyweight loss compared with disease controls (p > 0.05).