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Gingivitis
Published in Charles Theisler, Adjuvant Medical Care, 2023
Ascorbic acid and its relationship with periodontal disease is well-documented. In periodontal disease, vitamin C concentration is low in the blood plasma.1 Ascorbic acid deficiency has been shown to be a conditioning factor in the development of gingivitis.2 When humans are placed on ascorbic acid-deficient diets there is increased edema, redness, and swelling of the gingiva,3 which demonstrates that too little vitamin C can cause ascorbic acid-deficiency gingivitis.4 An older study demonstrated that 14 of 14 patients with gingivitis treated with large doses of ascorbic acid had favorable results.5
The Nutrition-Focused History and Physical Examination (NFPE) in Malnutrition
Published in Michael M. Rothkopf, Jennifer C. Johnson, Optimizing Metabolic Status for the Hospitalized Patient, 2023
Michael M. Rothkopf, Jennifer C. Johnson
Like the nails, hair is a skin appendage. It is a shaft of keratin formed by the hair follicle. The strength and character of the hair shaft is a function of nutritional status. Similarly, anchoring of the shaft at the follicle requires intact protein and micronutrients status. The sign you are looking for here is called “easy pluckability” of the hair shaft. Pulling on the hair will remove the shaft, often with a cellular matter attached. Ascorbic acid deficiency produces a specific set of findings with perifollicular hyperkeratosis, follicular hemorrhage and corkscrew hair strands.
Nutrition
Published in Jan de Boer, Marcel Dubouloz, Handbook of Disaster Medicine, 2020
Vitamin C (ascorbic acid) deficiency causes scurvy. Signs are swollen gums which bleed easily, and swollen painful joints. In infants subperiosteal haemorrhages can simulate paralysis of a limb. The deficiency occurs when fruits and vegetables are lacking. Gingival infection also causes bleeding gums; careful differential diagnosis is needed. Laboratory assessment of vitamin C status is by fluorometric determination of ascorbic acid in plasma.
Effect of high-dose intravenous vitamin C on point-of-care blood glucose level in septic patients: a retrospective, single-center, observational case series
Published in Current Medical Research and Opinion, 2021
Juan He, Guanhao Zheng, Xian Qian, Huiqiu Sheng, Bing Chen, Bing Zhao, Erzhen Chen, Enqiang Mao, Xiaolan Bian
Sepsis is a highly lethal clinical condition caused by systemic and inflammatory responses to infection that may result in hemodynamic abnormalities and multiple organ dysfunction syndrome (MODS)1. The basic treatment for sepsis includes anti-infectious treatment, source control, appropriate fluid resuscitation for maintenance of hemodynamic stability and vasopressors2. Ascorbic acid deficiency is widely observed in sepsis patients and associated with increased morbidity in critically ill patients; therefore, high-dose vitamin C (hdVC) is an essential adjunctive therapy for sepsis because of its cost-efficiency and clinical importance3. Potential mechanisms of vitamin C (VC) in sepsis treatment include amelioration of excessive oxidative stress and enhancement of cellular immune function1,4,5. High-dose intravenous VC is considered a safe treatment, with only a few case reports describing VC-associated calcium oxalate nephropathy as a main adverse effect2,6.
Cardiac involvement in beta-thalassaemia: current treatment strategies
Published in Postgraduate Medicine, 2019
Amal Paul, Viji S Thomson, Marwan Refat, Bader Al-Rawahi, Ali Taher, Sunil K Nadar
Peripheral vascular disease in thalassemia responds variably to iron chelation. Both deferasirox and deferiprone have been shown to improve endothelial function over time [55]. Although ascorbic acid deficiency causes impaired collagen formation in elastic arteries, ascorbic acid replacement not in conjunction with iron chelation therapy can potentially increase the labile iron levels. Lifestyle modifications that promote vascular health such as smoking cessation, regular physical activity, and weight reduction, should be actively promoted in thalassemia patients.