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General physical examination
Published in Fazal-I-Akbar Danish, Essential Lists of Differential Diagnoses for MRCP with diagnostic hints, 2017
Axillary lymphadenopathy:1 Lymph node enlargement (infective, e.g. viral prodrome, HIV infection, etc; malignant [reticulosis or primary tumour, metastases from ca. breast]).2 Drugs (phenytoin; retroviral drugs).
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis
Published in Journal of Investigative Surgery, 2019
Breast lumps usually grow rapidly in a short time and skin ulcers occur at the same time. Most of the masses of the patients were unilateral, consistent with the literature report 14. The proportion of masses located in the peripheral area of the breast was higher than that in the areola area (77% vs. 23%). It was reported that patients might have enlarged axillary lymph nodes and ipsilateral nipple retraction, which are similar to the signs of breast cancer.4,15,16 The patients in the study had axillary lymphadenopathy (13%), and ipsilateral papillary retraction (28%). The axillary lymph nodes of IGLM patients were tender and tough, but the border was clear, which is different with lymph nodes in tumor metastasis that were hard, had unclear boundaries, and were poorly mobile.
Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma
Published in OncoImmunology, 2019
Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
After cycle 1 of GBM.PVax, the patient developed confusion, and a brain MRI revealed increased T2/FLAIR indicative of edema/inflammation along with increased size of the T1 contrast-enhancing lesion most consistent with pseudoprogression (Figure 2(c)). Symptoms resolved completely with a short steroid taper, and a repeat brain MRI 4 weeks later showed a reduction in T2/FLAIR with stabilization of the T1 contrast-enhancing lesion (Figure 2(c)) coinciding with a significantly improved functional status. The patient continued to do well clinically through cycles 3 and 4 of GBM.PVax and noted interval development of axillary lymphadenopathy. Unfortunately, the subsequent brain MRI was concerning for disease progression (Figure 2(c)), and a repeat craniotomy with subtotal resection was performed. Histopathology demonstrated extensive treatment effect with only focal areas of residual glioma, and no overt tumor recurrence indicating the changes on the MRI was again due to pseudoprogression (Figure 2(d)). The post-surgical course was complicated by a saddle pulmonary embolus treated with embolectomy; intraparenchymal hemorrhage plus gastrointestinal bleeding from anticoagulation therapy resulting in a declining functional status that precluded additional GBM-related therapy. The patient passed away 21 months after initial diagnosis (Figure 1).
Vinorelbine’s anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas
Published in Journal of Chemotherapy, 2018
Meric A. Altinoz, Aysel Ozpinar, Ebru Emekli Alturfan, Ilhan Elmaci
First in 2005, Asakura reported an inflammatory breast cancer who responded to a combination of vinorelbine and trastuzumab.41 A 55-year-old woman presented with right axillary lymphadenopathy with unknown primary site of the disease. The patient chose to be treated by alternative medicine, but after about 6 months, she developed prominent bilateral neck and axillary lymph node swelling, diffuse right breast enlargement, redness and peau d’orange. A clinical diagnosis of inflammatory breast cancer was made and an overexpression of the human epidermal growth factor receptor 2 (HER2) was observed in the tumor specimen.41 She was treated with trastuzumab and vinorelbine and within 2 months, CT revealed a complete response in the lymph nodes, and the skin thickening and parenchymal edema of the right breast had improved.41 FDG-PET revealed no FDG uptake in either the right breast or the lymph nodes and the patient was alive for about 2 years at the time of their report.41