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Pathophysiology
Published in Ibrahim Natalwala, Ammar Natalwala, E Glucksman, MCQs in Neurology and Neurosurgery for Medical Students, 2022
Ibrahim Natalwala, Ammar Natalwala, E Glucksman
Which one of the following statements concerning ependymal cells is false? Ependymal cells are simple cuboidal epithelial cells.They line the ventricles and the central canal of the spinal cord.They provide trophic support and metabolic support for progenitor cells.The choroid plexus is responsible for the re-absorption of CSF.Abnormal ependymal adhesion may lead to hydrocephalus.
The effects of genotype × phenotype interactions on silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells
Published in Nanotoxicology, 2020
Tyler P. Nicholas, Anoria K. Haick, Tomomi W. Workman, William C. Griffith, James D. Nolin, Terrance J. Kavanagh, Elaine M. Faustman, William A. Altemeier
We compared genotype and phenotype effects for organotypic morphology and mRNA expression to achieve baseline characterization of organotypic cultures. We did not observe genotype effects on organotypic morphology; however, we observed phenotype effects on organotypic morphology (Figure 1). We perceived that organotypic morphology of the ‘T2-Skewed’ phenotype recapitulated clinical features of airway remodeling, marked by a shift toward a pseudostratified columnar epithelium with an abundance of epithelial glycoproteins. We noticed an increase in epithelial thickness due to cell proliferation (marked by blue-stained nuclei), shifted the simple cuboidal epithelium under the ‘Normal’ phenotype to the pseudostratified columnar epithelium under the ‘T2-Skewed’ phenotype. An increase in the density of ciliated cells is a distinguishing feature of pseudostratified columnar epithelium, which we also found on the apical surface under the ‘T2-Skewed’ phenotype. An increase in epithelial glycoproteins, including mucus and chitin (marked by unstained or light pink-stained inclusion bodies), is a distinguishing feature of T2 airway inflammation, which we also noted under the ‘T2-Skewed’ phenotype.
Toxic effect of carpet dust on the biochemical indices and histological structure of the lung in rats: the potential role of cytochrome P450 2E1 and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways
Published in Biomarkers, 2023
Abeer Salama, Rania Elgohary, Noha Mowaad, Doaa Sadek, Walaa Abdelhamid
The examination of H&E-stained rat lung sections of the control group revealed normal spongy lung architecture with bronchioles, blood vessels, alveolar sacs, and alveoli with thin interalveolar septa. Bronchioles appeared lined by a simple cuboidal epithelium with thin lamina propria followed by a thin layer of smooth muscle fibres and adventitia. The alveoli were separated by thin interalveolar septa and lined by type I and II pneumocytes. Type I pneumocytes appeared flat with flattened nuclei, and type II pneumocytes appeared cuboidal in shape with single rounded nuclei (Figure 6A and B).
Mesenchymal stem cells microvesicles versus granulocytes colony stimulating factor efficacy in ameliorating septic induced acute renal cortical injury in adult male albino rats (Histological and Immunohistochemical Study)
Published in Ultrastructural Pathology, 2022
Zeinab M Alazouny, Nabila M Alghonamy, Samar R Mohamed, Sara M Abdel Aal
Sections of the control (I) rats revealed the normal architecture of the renal cortex that was composed of both renal corpuscles and renal tubules. Each renal corpuscle consisted of a glomerulus (tuft of capillaries) surrounded by Bowman’s capsule, that was formed of visceral and parietal layers separated by Bowman’s space. The cortical renal tubules were formed of proximal and distal convoluted tubules mainly. They were lined by simple cuboidal epithelium with central rounded nuclei. The lumen of each distal convoluted tubule was wider than the proximal ones (Figure 4a).