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Role of Nutrition and Diet Therapy in Boosting Immunity
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Talbina is an Arabic dish made up of a combination of honey, barley and milk. The Prophet Muhammad PBUH suggested talbina for alleviating sorrows of the heart, for sadness and depression. It has a promising therapeutic and nutritional impact on health. Talbina is a rich source of several nutrients and bioactive components. Daily intake of talbina assists in preserving the health of the gastrointestinal tract and works as an antioxidant, antidiabetic, antidepressive, anti-inflammatory and antihypercholesterolemic. Furthermore, it is most efficient in removing toxins and providing nutrients to cells of the human body. According to the studies carried out for depression, it is associated with vitamin B deficiency (Mikkelsen et al., 2016). The talbina is a rich vitamin B source that is beneficial for the nervous system for making several chemicals that eventually have an impact upon psychological manifestation and mood in humans. So there is a rationale why Prophet Muhammad PBUH stated that talbina takes away sorrows and grief, as the human body can't store vitamin B, so it must be consumed daily. It is verified from several scientific studies that barley and its products assist in the prevention of cardiovascular disorders (Afzaal et al., 2021). Research has confirmed that talbina makes the mood better and inhibits depression (Murakami & Sasaki, 2010). Talbina consists of bioactive constituents that have immunomodulatory and antioxidant properties and are associated with the prevention of cancer (Guilloteau et al., 2010) (Figure 2.16).
Domain III: Communication
Published in Nicole M. Augustine, Prevention Specialist Exam Study Guide, 2023
It is important to understand the difference between listening and hearing. Hearing is the physiological process of sound waves being transformed into auditory nerve impulses (Hogan, 2003, p. 236). The process of listening is not the same as hearing; it requires paying close attention to what is being said and making sense of the information that has been received. The brain is a powerful organ in the human body and is capable of processing information quickly. Your brain can understand up to 400 words per minute. However, people only speak about 125–150 words per minute (Hogan, 2003, p. 237). This gap creates space for the receiver to be distracted by noise, and loss of attention minimizes clear understanding. Listening for understanding is truly an accomplished skill, which is why it is said ‘the best leaders are great listeners.’ Listening requires discipline of the mind, and once you understand this concept, you can translate this knowledge into making you a better overall communicator; sender and receiver.
Ethnopharmacology and Therapeutic Potential of Carica papaya
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Gurpreet Singh, Pooja Chawla, Abdul Faruk, Viney Chawla
Papain is a protein enzyme with cysteine protease, chymopapain, and lysozyme, which can accelerate the reaction within body cells. During the digestion process, pancreas commonly produces enzymes in the human body, these enzymes break down the foods into micronutrients, which can be used by the body for energy and other functions.12 Two main proteolytic enzymes (papain and chymopapain) in the latex of the papaya simply break down the proteins into amino acids through cleavage of the peptide bond. These proteins contained peptide bonds and can be easily broken down by enzymatic action into easily digestible micronutrients. It also helps to promote the digestion of wheat protein.40
The latest advances in high content screening in microfluidic devices
Published in Expert Opinion on Drug Discovery, 2023
Weiyu Liu, Jingyu Wang, Huibo Qi, Qisen Jiao, Lei Wu, Yu Wang, Qionglin Liang
The kidney is an important excretory organ that plays a crucial role in maintaining osmolality and natural homeostasis in the human body. The basic functional unit of the kidney is the nephron, which removes metabolites from the body via urine while retaining water and other nutrients through reabsorption [119–121]. Prior to clinical usage, new medications must be tested for effectiveness and safety, and preliminary tests for nephrotoxicity in animals are typical of such evaluations. However, animal studies are generally species-specific, time-consuming, costly, and do not accurately predict human nephrotoxicity. Additionally, animal studies are frequently associated with ethical issues [122,123]. While the ex vivo usage of cell lines reduces the ethical problems, some of these cell lines are derived from animals, and both human- and animal-derived immortalized cell lines are unable to completely recreate the structure and function of their native counterparts. Consequently, the development of a model that mimics the physiological outcome and function of the kidney in vivo is particularly important for both the drug screening and drug development.
Flavonoid constituents and protective efficacy of Citrus reticulate (Blanco) leaves ethanolic extract on thioacetamide-induced liver injury rats
Published in Biomarkers, 2023
Usama W. Hawas, Mohamed A. El-Ansari, Abeer F. Osman, Asmaa F. Galal, Lamia T. Abou El-Kassem
The liver is a critical organ in the human body that is responsible for the regulation of several metabolic functions and physiological processes. Its ability to detoxify xenobiotics makes it especially crucial for maintaining bodily health. Several mechanisms have been proposed to explain the hepatotoxicity of viral or non-viral hepatitis. In both cases, the cornerstone mechanisms are inflammation and oxidative stress-induced membrane lipid peroxidation (Tarocchi et al.2014). In addition, the liver’s self-healing and regenerative capacity can lead to excessive accumulation of extracellular matrix (ECM) proteins such as collagen, followed by progressive tissue scarring, cirrhosis, and loss of liver function. Despite advancements in contemporary medicine, there is no effective treatment strategy for enhancing liver regeneration, protecting the liver, or stimulating hepatic function (Madrigal-Santillán et al. 2014). Current drugs, such as pegylated interferon-alpha (IFN-α) and ribavirin, used to treat hepatitis virus infection, are not always successful in curing patients, and some of them may not tolerate this treatment. Similar restrictions have been found with silymarin, the most well-known hepatoprotective compound, when used to treat chronic liver damage such as cirrhosis. Thus, it is necessary to identify highly effective drugs for the treatment of liver diseases, emphasising their low toxicity.
Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer
Published in Drug Delivery, 2022
Nasrul Wathoni, Lisa Efriani Puluhulawa, I Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
The lungs are an important organ in the human body, particularly in the respiratory system. Damage to this organ can endanger lives and perhaps result in death. Lung cancer is a form of cancer that affects the human lungs (Bade & Dela Cruz, 2020). This malignancy is the second most common after breast cancer and has the greatest fatality rate of any type of cancer (International Agency for Research on Cancer (IARC), 2020). It is reported that this cancer has a mortality rate of 1,796,144 or 18% of the total number of cancer deaths and an incidence rate of 2,206,771 which is 11.4% of all cancer incidences worldwide both in women and men (Globocan, 2020). There are currently three options for cancer treatment: surgery, radiation therapy, and chemotherapy (Abbas & Rehman, 2018). Stage I or II Non-Small Cell Lung Cancer ‘NSCLC’ treatment is surgical resection of the tumor followed by adjuvant therapy. When the cancer progresses to stage III or IV, the treatments are chemotherapeutic and/or radiation therapy. Since the cancer invaded surrounding tissues, metastases can occur through the circulatory system or lymphatic system (Huang et al., 2015). Chemotherapy is a form of cancer treatment that employs medications. As a result of the drug’s inability to target specific cells, this therapy is often associated with severe adverse effects (Ohnoshi et al., 1992; Partridge et al., 2001; Sun et al., 2005; Aslam et al., 2014). It has inspired the development of cancer medicines, one of which is the use of nanoparticles.