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Orthopaedics and musculoskeletal system
Published in Jagdish M. Gupta, John Beveridge, MCQs in Paediatrics, 2020
Jagdish M. Gupta, John Beveridge
Manifestations of juvenile rheumatoid arthritis include unexplained high fever (Still's disease), stiffness of the joints in the morning, skin rash, which may be evanescent, and generalized lymphadenopathy. Rheumatoid factor may be found but is not specific to rheumatoid arthritis.
Fibromyalgia
Published in Michael S. Margoles, Richard Weiner, Chronic PAIN, 2019
The symptoms of malaise, fatigue, myalgia, and arthralgia accompany many connective tissue diseases. Patients with early rheumatoid arthritis may have a positive test for rheumatoid factor despite evanescent physical findings of synovitis or other evidence of articular inflammation. The response of the patient with rheumatoid arthritis to large doses of salicylates is greater than that of the patient with FS, although the latter may obtain some relief.
The locomotor system
Published in Peter Kopelman, Dame Jane Dacre, Handbook of Clinical Skills, 2019
Peter Kopelman, Dame Jane Dacre
Rheumatoid factor This is positive in the majority of patients with rheumatoid arthritis. However, rheumatoid disease can be present with a negative rheumatoid factor. This emphasises that rheumatoid arthritis is a clinical diagnosis.
LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis
Published in Biomarkers, 2023
Xuemeng Chen, Li Xie, Yi Jiang, Ronghua Zhang, Wei Wu
More and more studies have shown that RA is related to immune disorders, endocrine factors, genetics, external environment, etc., and comprehensive factors lead to chronic inflammatory lesions of joints (Balandraud and Roudier 2018, Giannini et al. 2020). At present, we commonly use magnetic resonance imaging, ultrasound and serum markers such as rheumatoid factor for early detection and clinical diagnosis of RA. Nonetheless, none of these approaches enables efficient diagnosis and treatment (Groves et al. 2017). Rheumatoid factor is not a specific antibody for rheumatoid arthritis. Autoantibodies to citrullinated proteins (antiperinuclear factor, anti-keratin antibodies and anti-cyclic citrullinated peptide antibodies), however, have a much higher specificity for RA. Of these, anticyclic citrullinated peptide antibodies are of special interest because of their high sensitivity and specificity for RA and their ability to predict erosive arthritis. These autoantibodies may serve as a powerful serologic marker for early diagnosis and prognosis for RA (Raptopoulou et al. 2007). Therefore, it is of great significance to find more effective diagnostic methods and more reliable potential molecules for RA.
New Findings on Autoimmune Etiology of Idiopathic Granulomatous Mastitis: Serum IL-17, IL-22 and IL-23 Levels of Patients
Published in Journal of Investigative Surgery, 2021
Mehmet Saydam, Kerim Bora Yilmaz, Mutlu Sahin, Hamdullah Yanik, Melih Akinci, Ibrahim Yilmaz, Sener Balas, Cem Azili, Mehmet Ali Gulcelik
The classic serological tests used in autoimmune diseases may give different results in IGM patients. Ozel et al. found rheumatoid factor (RF) serological tests to be positive in 6 patients, and anti-nuclear antibody (ANA) and anti-double stranded DNA antibodies positive in 2 patients in their study conducted with 8 IGM patients [18]. In another study by Asoglu et al. none of the 18 patients diagnosed with IGM were ANA- or RF-positive [19]. Altintoprak et al. determined that the role of autoimmune factors in the etiology of IGM, such as dominant ANA and the presence of an extractable nuclear antigen, could not be identified in their study on the presence of definite autoantibodies associated with autoimmunity in patients with IGM [12]. In addition, the association between serum IL-33 and IGM could not be shown statistically in a study conducted by Yigitbasi et al [20].
Value of serum collagen triple helix repeat containing-1(CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis
Published in British Journal of Biomedical Science, 2021
T Hu, Y Liu, L Tan, J Huang, J Yu, Y Wu, Z Pei, X Zhang, J Li, L Song, W Dai, Y Xiang
RA is a chronic and progressive autoimmune disease, which mainly involves the synovial tissue of the joint, and is accompanied by hyperplasia of the pannus and progressive bone destruction, which eventually leads to loss of joint function. Its primary aetiology and pathogenesis are still unclear. Rheumatoid factor, ESR and anti-CCP are routine serological test indicators for the diagnosis of RA. The combination of clinical manifestations and imaging examinations can help to diagnose RA patients. However, increased rheumatoid factor is often detected in sera of inflammatory diseases, other autoimmune diseases and even healthy older adults [8], resulting in its low specificity for RA. Therefore, more sensitive and specific serological indicators would be of value in the diagnosis of RA.