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Vasculitides
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Ivy M. Obonyo, Virginia A. Jones, Kayla A. Clark, Maria M. Tsoukas
Microscopically, LCV can be seen as well as inflammation, predominantly neutrophils with some eosinophils and lymphocytes, of the capillary and postcapillary venule. Extravasated erythrocytes found perivascularly and in the interstitium with fibrin deposition may also be seen. On immunofluorescence, immunoglobulins, complement, and/or fibrinogen may be seen in a granular pattern. These findings help differentiate urticarial vasculitis from chronic allergic urticaria, which is characterized by lymphohistiocytic perivascular cuffing without extravasated erythrocytes.
Introduction to dermatological diagnosis
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
This identifies an immediate hypersensitivity reaction in asthma, hay fever or allergic urticaria (contact urticaria to fragrances is done by short contact patch testing). It is not of any use in the diagnosis of atopic eczema or idiopathic urticaria. It is useful in identifying natural rubber latex allergy.
Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials
Published in Pharmaceutical Biology, 2021
Yulong Wen, Yidan Tang, Miaoyue Li, Yu Lai
Type I allergic urticaria is most common in clinical work. Serum IgE, as one of the important indicators reflecting the degree of allergic reaction in the body, plays a key role in mutational reactive diseases (Zhu et al. 2017). Meanwhile, IgE may be related to CD4+ T and CD8+ T cell levels in the body. Previous reports have suggested that altering the proportions of T lymphocyte subsets can lead to CU (Li et al. 2010). Another study also confirmed that CD4+ T cells play a major role in antigen recognition in the CU. The decrease in CD4+ T cells and the increase in CD8+ T cells may lead to CU (Zhu et al. 2021). According to its possible pathogenesis and the current treatment recommendations, our group chose to assess the efficacy of desloratadine in combination with compound glycyrrhizin in treating CU.
Cost-effectiveness of using an extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG in managing IgE-mediated cow’s milk protein allergy in the UK
Published in Current Medical Research and Opinion, 2019
Allergic urticaria was diagnosed if at least two episodes of itching eruptions or swelling with typical appearance were observed by the parents or a physician and were caused by the same allergen. Atopic eczema was diagnosed based on pruritus, typical morphology and distribution, a chronic or chronically relapsing course, and personal or family atopic history. Allergic rhinoconjunctivitis was diagnosed based on the symptoms of rhinitis, such as nasal congestion, sneezing, itching, rhinorrhoea, current use of medication for these symptoms and/or conjunctivitis, after exclusion of infection. A diagnosis of asthma was based on the presence of recurrent wheeze (more than once a month), difficulty in breathing, chest tightness or both; cough (worse at night); clinical improvement during treatment with short-acting bronchodilators and inhaled steroids; and worsening when treatment was stopped. Alternative causes of recurrent wheezing were considered and excluded12.
Allergen immunotherapy: progress and future outlook
Published in Expert Review of Clinical Immunology, 2023
Lara Šošić, Marta Paolucci, Stephan Flory, Fadi Jebbawi, Thomas M. Kündig, Pål Johansen
Allergy affecting the skin can be associated with high levels of allergen-specific or total IgE. While allergic urticaria and angioedema are categorized as immediate-type allergic diseases, AD and CD are classified as delayed-type hypersensitivity reactions, the pathomechanism being mainly based on T cells in the skin and not on IgE-dependent mast-cell degranulation. The management of allergen-triggered urticaria and angioedema is generally based on trigger avoidance, high-dose daily antihistamines, and/or biologicals [6]. The management of AD and CD includes a combination of trigger avoidance and topical treatment with emollients, anti-inflammatory products, and/or biologicals.