China
Africa
Explore chapters and articles related to this topic
Cyclodextrin-Based Nanosystems: Current Status and Future Prospects
Published in Costas Demetzos, Stergios Pispas, Natassa Pippa, Drug Delivery Nanosystems, 2019
Cem Varan, Gamze Varan, Nazli Erdoğar, Erem Bilensoy
Nanosponges, which are the colloidal structures of hyper-cross-linked polymers, have been especially developed in recent years, and interest in these structures is increasing. Nanosponges have several advantages, especially increasing the solubility of drugs with low solubility, having higher encapsulation efficacy, and prolonging drug release. In addition, nanosponges can be designed in different dosage forms, such as oral, parenteral, topical, and inhalation. Methods such as simple thermal desorption, extraction with solvents, microwave use, and ultrasonic techniques can be used to prepare CD nanosponges. CD nanosponges are prepared to eliminate problems of drugs such as solubility, permeability, and sensitivity; ensure effective and safe dosage forms, enhance drug-loading capacity; and prolong drug release [52].
Nano Resveratrol: A Promising Future Nanonutraceutical
Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019
Chahinez Houacine, Kamalinder K. Singh
Cyclodextrin-based nanosponges present a modern approach for highlighting the progression, which could be brought about by nanotechnology-based delivery systems (Chilajwar et al., 2014). Nanosponges (Figure 10.4c) are the sponges with size of about a virus, which can be occupied with a wide variety of drugs. These minute sponges tend to circulate within the body until they meet the specific target site(s) to release the drug in a controlled and predictable manner. As they can cater to the site-directed drug delivery, they possess vibrant opportunities in drug delivery. Because of their high aqueous solubility, nanosponges have been found effective for bioactives with poor solubility (Subramanian et al., 2012). Nanosponges offer high loading efficiency vis-à-vis other nanocarriers. Controlled release of the loaded bioactives and solubility enhancement of poor water-soluble substances are the major advantages of nanosponge delivery systems.
Application of Nanobioformulations for Controlled Release and Targeted Biodistribution of Drugs
Published in Anil K. Sharma, Raj K. Keservani, Rajesh K. Kesharwani, Nanobiomaterials, 2018
Josef Jampílek, Katarina Král’ová
Nanosponges can be referred to as solid porous particles having a capacity to load drugs into their nanocavity, they can be formulated as oral, parenteral, topical, or inhalation dosage forms, they offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility, and delayed release of actives (Tejashri et al., 2013). CD-based nanosponges are innovative cross-linked CD polymers nanostructured within a three-dimensional (3D) network that are proposed as new nanoscale delivery systems. They form porous NPs with sizes <500 nm, spherical shape, and negative surface charge and show a good capacity for incorporating small molecules, macromolecules, ions, and gases. CD-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules and be used also for site-specific targeting by conjugating various ligands on their surface (Trotta et al., 2012, 2014). The insight into CD-based nanosponges, including their physical and chemical properties, methods of their preparation and characterization, biocompatibility, and their use as effective drug formulations, was presented by Chilajwar et al. (2014).
Hierarchy analysis of different cross-linkers used for the preparation of cross-linked cyclodextrin as drug nanocarriers
Published in Chemical Engineering Communications, 2018
R. Pushpalatha, S. Selvamuthukumar, D. Kilimozhi
Cyclodextrins when reacted with cross-linkers like hexamethylene diisocyanate and toluene diisocyanate result in carbomate-bonded nanosponges. The cross-linkers are used with cyclodextrin in the molar ratio of 1:2 to 1:8. These nanosponges can be prepared by solvent method at temperature ranging from room temperature to 70°C under anhydrous/nitrogen atmosphere. Residual solvent can be removed using acetone. These nanosponges are initially developed for purification of water, including removal of nitrophenol, dissolved organic carbon. Recent research focuses on preparing molecular-imprinted nanosponges using these diisocyanate cross-linkers for encapsulation of dextromethorphan, steroids, dyes, and naringin (Takayuki Hishiya et al., 1999; Roche et al., 2009; Ma et al., 2011; Kyzas et al., 2013; Swaminathan et al., 2013).