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Droplet-Based Microfluidics for Biological Sample Preparation and Analysis
Published in Eric Lagally, Krzysztof Iniewski, Microfluidics and Nanotechnology, 2017
Droplet-based microfluidics has developed substantially as a technology and will likely assume a higher-profile role in biological analyses in the future. Not only are much smaller amounts of reagents and samples consumed, but also thousands of reactions and screening experiments can be performed within droplets simultaneously. Perhaps more importantly, droplet-based microfluidics is a promising tool to help us understand some fundamental biological processes such as enzymatic reactions in a confined and crowding environment, protein–protein and protein–ligand interactions, interfacial functions in biological systems, and single-cell proteomics and metabolomics. A number of operational units have been well developed for droplet-based microfluidics, including droplet generation, fusion, and incubation. Others, such as droplet extraction for subsequent analysis of the contents, have been developed recently and promise to add versatility to the platform. Robust integration of multiple functions to create a true “lab-on-a-chip” continues to be a challenge, but the unique advantages of droplets for sample-limited biological analyses will undoubtedly spawn further development and we anticipate significant growth in the number of applications that rely on this technology in coming years.
Droplet-Based Microfluidics for Biological Sample Preparation and Analysis
Published in Kevin Yallup, Krzysztof Iniewski, Technologies for Smart Sensors and Sensor Fusion, 2017
Droplet-based microfluidics has developed substantially as a technology and will likely assume a higher profile role in biological analyses moving forward. Not only are much smaller amounts of reagents and samples consumed but also thousands of reactions and screening experiments can be performed within droplets simultaneously. Perhaps more importantly, droplet-based microfluidics is a promising tool to help us understand some fundamental biological questions such as enzymatic reactions in a confined and crowding environment, protein–protein or protein–ligand interactions, interfacial functions in biological systems, and single-cell proteomics and metabolomics. A number of operational units have been well developed for droplet-based microfluidics, including droplet generation, fusion, and incubation. Others, such as droplet extraction for subsequent analysis of the contents, have been developed recently and promise to add versatility to the platform. Robust integration of multiple functions to create a true lab-on-a-chip continues to be a challenge, but the unique advantages of droplets for sample-limited biological analyses will undoubtedly spawn further development, and we anticipate significant growth in the number of applications that rely on this technology in the coming years.
Biological Sample Preparation and Analysis Using Droplet-Based Microfluidics
Published in Šeila Selimovic, Nanopatterning and Nanoscale Devices for Biological Applications, 2017
Droplet-based microfluidics has developed substantially as a technology will likely assume a higher-profile role in biological analyses moving forward. Not only are much smaller amounts of reagents and samples consumed, but also thousands of reactions and screening experiments can be performed within droplets simultaneously. Perhaps more importantly, droplet-based microfluidics is a promising tool to help us understand some fundamental biological questions such as enzymatic reactions in a confined and coasis:rowded environment, protein–protein or protein–ligand interactions, interfacial functions in biological systems, and single-cell proteomics and metabolomics. A number of operational units have been well developed for droplet-based microfluidics, including droplet generation, fusion, and incubation. Others, such as droplet extraction for subsequent analysis of the contents have been developed recently and promise to add versatility to the platform. The robust integration of multiple functions to create a true “lab-on-a-chip” continues to be a challenge, but the unique advantages of droplets for sample-limited biological analyses will undoubtedly spawn further development and we anticipate significant goasis:rowth in the number of applications that rely on this technology in the coming years.
Scale-up modeling for manufacturing nanoparticles using microfluidic T-junction
Published in IISE Transactions, 2018
Yanqing Duanmu, Carson T. Riche, Malancha Gupta, Noah Malmstadt, Qiang Huang
Synthesis of solid particles, liquid droplets, and gas bubbles is critical for pharmaceutical and chemical engineering applications (Demello, 2006; Wang, Jiao, Huang, Yang, and Nguyen, 2009; Xu et al., 2009). Droplet-based microfluidic devices manipulate immiscible fluids in channels of micrometer size (Thorsen et al., 2001; Anna et al., 2003; Link et al., 2004; Garstecki et al., 2006; Christopher and Anna, 2007; Christopher et al., 2008; Fu et al., 2009; Tan et al., 2009; Zhao and Middelberg, 2011). The high surface-area-to-volume ratio within microchannels guarantees a uniform temperature throughout the reaction volume, and convective mixing within droplets ensures rapid homogenization. These properties make droplet microfluidic reactors a viable technology for the scalable synthesis of high-quality metal nanoparticles.