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The Basic Concept for Microfluidics-Based Devices
Published in Raju Khan, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, A. B. P. Mishra, Advanced Microfluidics-Based Point-of-Care Diagnostics, 2022
To fabricate a microchannel for a given application, the factors such as materials, design, and fabrication processes are selected accordingly. A large variety of materials is used for the fabrication of microfluidics reactors, as illustrated in Figure 1.26. Silicon was the first material to be worked upon for the manufacturing of microfluidics devices followed by glass and other materials. However, with the advancements in science and technology, materials such as polymers, composites, and paper have gained much popularity for the fabrication of microreactors. In translation from the laboratory to industrial scale, priority is given to the cost of production, performance, and reliability. Thus, a crucial aspect is to bridge the balance between the materials and fabrication techniques in order to bring down the final cost of the product.
Nanobiotechnology Advances in Bioreactors for Biodiesel Production
Published in Madan L. Verma, Nanobiotechnology for Sustainable Bioenergy and Biofuel Production, 2020
Bhaskar Birru, P. Shalini, Madan L. Verma
Microfluidic devices or microcapillary reactor uses the microchannels for the enzymatic reaction. Various materials such as polymers, glass and silicon were used for the fabrication of microreactors. GC and LC parts also can be used for microreactor fabrication. Silicon and polymers possess the light transmission ability, which is the reason for the ease of using these reactors for analyzing the product with the help of optical techniques. The use of transparent materials for microreactor fabrication enables the continuous monitoring of biochemical reactions. Thus, polydimethylsiloxane (PDMS) and poly methyl methacrylate (PMMA) are preferred in the fabrication of microreactors. Both these materials are biocompatible, light transparent and require surface modification for improving the wettability properties (Kecskemeti and Gaspar 2018).
Synthesis and Assembly of Inorganic and Inorganic–Organic Hybrid Nanomaterials by Microreactor-Assisted Chemical Processes
Published in Sivashankar Krishnamoorthy, Krzysztof Iniewski, Nanomaterials, 2017
Ki-Joong Kim, Chang-Ho Choi, Seung-Yeol Han, Chih-Hung Chang
Metal NPs have been synthesized successfully using a number of different microreactors. One simple example of a continuous flow reactor consisting of a helical coil in a heated oil bath is shown in Figure 2.1a.53 The metal precursor is mixed with growth solutions, and the mixture is then directed into temperature-controlled tubing. The capillary tubing, having microscale internal dimensions, improves size and composition control in the NP synthesis, which is due in large part to more precise temperature control. Microreactors used in all cases have been shown to offer significant advantages over similar batch reactors as a result of increased reaction control and the ability to fine-tune the final product.
Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review
Published in Drying Technology, 2023
Ankit Patil, Pritam Patil, Sagar Pardeshi, Preena Shrimal, Norma Rebello, Popat B. Mohite, Aniruddha Chatterjee, Arun Mujumdar, Jitendra Naik
Microreactor is a chemical reactor consisting of confinement known as microchannels in which the chemical reaction occurs. Microchannels must be fabricated using PDMS (Poly-Di-Methyl-Siloxane), Glass, Silicon, Quartz, etc. material depending on its chemical compatibility. Among them, glass is widely accepted due to its inertness. The diameter of these confinements is significantly smaller. Thus, microreactors have a large surface-to-volume ratio, which efficiently controls highly exothermic reactions and reaction conditions, i.e., temperature with reasonable safety. It also provides high mass transfer and heat transfer area, a good flow regime, etc.
Effect of channel dimension on biodiesel yield in millireactors produced by stereolithography
Published in International Journal of Green Energy, 2021
Marija Lukić, Domagoj Vrsaljko
Techniques used for the fabrication of microreactors are similar to the ones well established in microelectronics and semiconductor industries. Microcapillary reactors are fabricated from suitable tubing of desired length and material, while chip-based reactors employ glass, silicone, or plastics that are processed by micromachining, wet etching and lithography techniques (Chizari, Shaw, and Hopkins 2019; Kiani, Venkatakrishnan, and Tan 2013; Phillips 2014). On the other hand, bonding of substrate layers to enclose the channels still remains the most critical and inconsistent step in microfluidic chip fabrication (Tsao and Devoe 2009).