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o-toluidine
O-toluidine is a colorless to light-yellow liquid with a weak aromatic odor, soluble in water and very soluble in organic solvents and dilute acids. It has a boiling point of 200°C, a flash point of 85°C (closed cup), and a density of 1.008 at 20°C. Exposures to o-toluidine can cause toxicity and poisoning to animals and occupational workers. O-toluidine is used in the manufacture of various dyes and as an intermediate in rubber chemicals and pharmaceuticals. The N-oxidized metabolite of o-toluidine, N-hydroxy-o-toluidine, has been found to be mutagenic in S. typhimurium strain TA100, and other reported effects of o-toluidine include the induction of sister chromatid exchange, aneuploidy, unscheduled DNA synthesis, DNA strand-breaks, and cell transformation in vitro, and the induction of micronuclei in peripheral blood of rats treated in vivo. There is moderate mechanistic evidence indicating that the carcinogenicity of ortho-toluidine involves metabolic activation, formation of DNA adducts, and induction of DNA-damaging effects.From: Illustrated Dictionary and Resource Directory of Environmental and Occupational Health [2019], and Safety [2016], Overview of biological mechanisms of human carcinogens [2019], Handbook of Environmental Analysis [2017], Separation and concentration of o–toluidine and tricyclazole from water with micellar enhanced ultrafiltration based on sodium dodecyl sulfate surfactant
[2021]
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