Metolachlor

Metolachlor

Product: Alfa-Tox

Published in Charles R. Foden, Jack L. Weddell, First Responder’s Guide to Agricultural Chemical Accidents, 2018

HEALTH HAZARD INFORMATION: Product is a choloacetamide inhibitor. Exposure may cause irritation of the eyes, skin and respiratory tract. A skin (allergic) reaction may occur occasionally in sensitive individuals. Exposure to metolachlor is reported to cause headache, nausea and vomiting, usually subsiding within 24 hours.A physician should be contacted if anyone develops any signs or symptoms and suspects that they are caused by exposure to this product.

An expedient and rapid green chemical synthesis of N-chloroacetanilides and amides using acid chlorides under metal-free neutral conditions

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Journal Information

Published in Green Chemistry Letters and Reviews, 2018

B. S. Balaji, Neha Dalal

Chloroacetyl chloride (CAC) (26) is an important two carbon bifunctional unit widely used in synthetic chemistry (27). It is used as a protecting group (28) for alcohols and amines. The acid chloride part is used in many acylation reactions with alcohols, amines, (29–32) alkynes (33) and also in Friedel–Crafts reactions (34, 35). Similarly the α-chlorine can be replaced by many nucleophiles (OH─, NH2─, SH─ etc.) through SN2 displacement (36–39). Many chloroacetamides are used as herbicides such as alachlor [15972-60-8], metolachlor [51218-45-2].

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Product: Alfa-Tox

An expedient and rapid green chemical synthesis of N-chloroacetanilides and amides using acid chlorides under metal-free neutral conditions