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Recent Advancements on Nano-Based Drug Delivery System for Targeted Cancer Therapy
Published in Pradipta Ranjan Rauta, Yugal Kishore Mohanta, Debasis Nayak, Nanotechnology in Biology and Medicine, 2019
Similar to the ferrocene, titanocene complexes have also been found to exhibit activity against cancer cells. [Ti(h5-C5H5)2Cl2] titanocene dichloride contains a cis-dichlorido motif that might be an analog to cisplatin as it forms a similar 1,2 GG intra-strand crosslink in the DNA. However, after a decade of research and clinical trials, the titanocene dichloride was withdrawn mainly due to its solubility issue in water, non-selectivity, and hydrolytic stability, along with a poor understanding of its mechanism of action for exerting cytotoxicity.
Organometallic-Mediated Radical Polymerization
Published in Samir H. Chikkali, Metal-Catalyzed Polymerization, 2017
Daniel L. Coward, Benjamin R. M. Lake, Michael Shaver
The earliest example of using titanium in radical polymerization appeared in 2003.60 Titanocene dichloride, Cp2TiCl2 (20, Cp=cyclopentadienyl) (Figure 6.15), was used as a chain growth mediator in the polymerization of MMA, initiated by AIBN. Dispersities were broad (Đ = 1.9–2.9) implying only a low degree of control. Further studies showed that the method of control was due to reduction of 20 to the titanium(III) analogue (21).20
Crystalline bis(η5-cyclopentadienyl)bis(benzoato/carboxylato)titanium(IV) precursor-directed route to functional titanium dioxide nanomaterials
Published in Journal of Coordination Chemistry, 2018
Tushar S. Basu Baul, Rajesh Manne, Edward R. T. Tiekink
A freshly prepared solution of titanocene dichloride (0.25 g, 1.004 mmol) in anhydrous benzene (15 mL) was added to a stirred suspension of sodium 4-methylbenzoate (0.396 g, 2.504 mmol) in anhydrous benzene (15 mL) and the stirring was continued at 40 °C for 4 h. During reaction, the color of the reaction mixture changed from blood-red to bright-orange. The orange solution was filtered through a frit covered with pre-dried neutral silica (1 cm layer, mesh size 100–200) and eluted further with anhydrous benzene (3 × 0.5 mL). The clear filtrate was concentrated using a rotary evaporator to around 5 mL and precipitated with excess anhydrous hexane. The orange solid was collected on a frit, washed with hexane (2 × 5 mL), dried, and recrystallized from anhydrous toluene under ambient conditions to afford orange crystals of 1 at ambient temperature. Yield: 0.27 g, 55%. m. p.: 176–178 °C (dec.) 174–176 °C (dec.) [39]. IR absorption (cm−1) 1625 ν(OCO)asym, 1574, 1446, 1335 ν(OCO)sym, 1306, 1289, 1169, 1135, 1020, 808, 756, 611, 570, 467. 1H NMR (CDCl3): 7.87 (d, J = 8.6 Hz, 4H, H-2/H-6), 7.18 (d, J = 8.6 Hz, 4H, H-3/H-5), 6.54 (s, 10H, C5H5), 2.36 (s, 6H, CH3) ppm. 13C{1H} NMR (CDCl3): 172.3 (COO), 142.2 (C-1), 130.9 (C-4), 130.0 (C-2/C-6), 128.9 (C-3/C-5), 118.4 (C5H5), 21.6 (CH3) ppm.
Theoretical understanding the effects of external electric field on the hydrolysis of anticancer drug titanocene dichloride
Published in Molecular Physics, 2020
Second hydrolysis: Figure 1 shows the structures of the reactant adduct (RA1 and RA2), the transition state (TS1 and TS2) and the product adduct (PA1 and PA2) in the hydrolysis of titanocene dichloride.