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Clinical Effects of Pollution
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 5, 2017
William J. Rea, Kalpana D. Patel
Some of the alteration of the lymphatics and the microvascular dysfunction may be due to attraction of the BBB of both the vessels and the lymphatics due to organophosphates pesticide.92 However, it may also be triggered by head trauma that is so mild that nothing shows on brain scan.93 Researchers at the Cleveland Clinic and Soroka Medical School and Korn et al.93 have shown that 17 patients with neurologic symptoms revealed abnormal patterns as the generator for abnormal rhythms. SPECT scans showed local reduction of perfusion in 70%–85% of the patients. These areas were closely related to the anatomic location of the BBB lesion. These data are paired to focal cortical dysfunction in conjunction with BBB disruption. These hits can trigger the autoimmune responses; S100B protein in the blood seems to be an indicator of significant head trauma. According to Friedman et al.,94 pyridostigmine brain penetration under stress enhances neuro net excitability and induces early immediate transcriptional responses. Pyridostigmine (PYR) obtains 20%–20% whole blood acetylcholinesterase (AGhE) inhibits, which change the treatment of poisoning by an organophosphate anticholinesterase agent. Thus, when the trauma occurs in humans, it could be a nidus for subsequent trigger of CS as we have seen in many patients at the EHC-Dallas.
Outdoor Emissions
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
According to Golomb,544 a range of “unrelated” exposures are linked to GWI which can cause OS and MD. Acetylcholinesterase inhibitor (AChEI) exposures (organophosphates, as nerve agents, pesticides; and carbamates, as pesticides and pyridostigmine bromide nerve agent pretreatment pills), show especially strong and consistent links to health problems in GWV.544 Moreover, AChEI shows a dose–response relationship to GWI (number of pyridostigmine bromide pills544; and proximity to the Khamisiyah munitions depot demolition (sarin nerve agent plume) is linked to the extent of brain atrophy and neuropsychological dysfunction in GWV.820,821 Additional findings extend to genetic evidence such as peroxidase variants.671 These support a causal association of AChEI to the GWI,544 so mechanisms of toxicity by AChEI(s) are of special interest, (GWV/GWI(s) are also linked to reduced peroxidase activity levels671,674; however, low activity may be the effect and/or cause of paraoxonase735,822 and other elements of organophosphate detoxification,761 as well as low paraoxonase activity.576 Our series of OS (i.e., nutrients and paraoxonase) has been quite impressive as shown by Alter and Organiziac. Peroxidase was definitely involved in some non-GW chemically sensitive patients who were exposed to natural gas, pesticides, formaldehyde, solvents, etc.
Open source modular ptosis crutch for the treatment of myasthenia gravis
Published in Expert Review of Medical Devices, 2018
Trust Saidi, Sudesh Sivarasu, Tania S. Douglas
Advances during the last century have resulted in various treatments for MG. Cholinesterase inhibitors are used to retard the degradation of acetylcholine at the neuromuscular junction [46]. There are challenges in the use of cholinesterase inhibitors such as pyridostigmine bromide and neostigmine [7,47]. Although pyridostigmine bromide is the most common first treatment and is considered effective particularly during the early phases of the disease, most patients experience muscarinic side effects of nausea, abdominal cramping, and diarrhea [7,34]. Neostigmine is rarely used because of its poor tolerability and pharmacodynamic profile [7]. Consequently, cholinesterase inhibitor treatment is inadequate for the vast majority of MG patients, and as a result, immunosuppressive corticosteroids, particularly prednisone, is prescribed [48]. Although corticosteroids are inexpensive and rapid-acting drugs for immunomodulation in MG [49], their use is limited by multiple side effects such as osteoporosis, diabetes mellitus, infection, gastric ulcer, and glaucoma [50].