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Pleural disease induced by drugs
Published in Philippe Camus, Edward C Rosenow, Drug-induced and Iatrogenic Respiratory Disease, 2010
Penicillamine, a chelating agent for copper, exhibits immunosuppressive effects and is approved for the treatment of Wilson’s disease; however, it also has been used in the treatment of autoimmune diseases because of its immunosuppressive action. Adverse effects associated with d-penicillamine include blood dyscrasias (neutropenia, thrombocytopenia, haemolytic anaemia and aplastic anaemia), dermatitis (Stevens–Johnson syndrome and pemphigus), conditions that mimic other autoimmune diseases (rheumatoid arthritis, Goodpasture’s syndrome, lupus erythematosus and myasthenia gravis), and nephrotic syndrome.
The detoxification of cadmium in Japanese quail by pomegranate peel powder
Published in International Journal of Environmental Health Research, 2023
Maryam Karimi-Dehkordi, Morteza Molavi Pordanjani, Majid Gholami-Ahangaran, Amin Mousavi Khaneghah
The primary mechanisms in metal poisoning are oxidative stress and free radical formation (Lopes et al. 2016). The free oxygen radicals are highly active and very mobile. Therefore, they immediately initiate chain reactions and damage proteins, fats, and DNA (Malekirad et al. 2019). Oxidative stress and free radicals resulting from exposure to toxic metals, e.g. Cd, Fe, and Pb, alter cellular gene expression, ultimately leading to cell proliferation and increasing the tumor potential (Subastri et al. 2018). In the poisoned animal or human, liver, nerve, or kidney cell damage may occur (Shariatifar et al. 2020; Karimi et al. 2021). Oxygen-free radicals and other reactive oxygen species (ROS), formed in all aerobic organisms, have various essential roles. Nonetheless, some of them can potentially cause damage (oxidative damage) to biomolecules, resulting in the development and progression of certain diseases, especially cancer, and neurodegenerative disorders, such as Parkinson’s and Alzheimer’s (Alkadi 2020). Different technologies have been utilized to remove a toxic element from diets, e.g. applying chelators and trapping free radicals by psychobiotic and synthetic antioxidants. The use of nanoparticles, traditional and new chelating agents, and combination therapy can be considered in removing Cd from a biological system. Chelating agents such as Ethylenediaminetetraacetic acid (EDTA), Penicillamine (DPA), Dimercaprol, Dithiocarbamates, Meso 2, 3-dimercaptosuccinic acid (Succimer, DMSA), and New DMSA analogs can be used to reduce toxic concentrations in the body (Rahimzadeh et al. 2017). Nanoparticles, e.g. Al2O3 and Carbon nanotubes (CNTs), remove Cd ions from biological solution systems (Gadhave 2014). Plasma exchange-hemodialysis-plasmapheresis can be helpful in heavy-metal toxicity (Russi and Marson 2011).
Novel copper complexes-polyurethane composites that mimics anti-inflammatory response
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Guido Antonio Zapata-Catzin, Gualberto Antonio Zumbardo-Bacelis, Rossana Vargas-Coronado, Jorge Xool-Tamayo, Victor Ermilo Arana-Argáez, Juan Valerio Cauich-Rodríguez
Copper ions can bind to a large number of ligands, obtaining useful compounds. For example, penicillamine is used for the treatment of cystinuria and rheumatoid arthritis but also can form copper-thiol complexes which are commonly used for the treatment of Wilson’s disease, where de D isomer is more effective due to its higher chelating capacity [20].