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Published in Joseph C. Salamone, Polymeric Materials Encyclopedia, 2020
Polymers which have many aromatic cyclics in their chain structure tend to be stiff and resistant to deformation. The synthesis of such polymers usually requires the use of a thermal stable rigid structure in the backbone chain units. The polymer also shows extra thermal stability. It can be considered a weak base resin because of the presence of pyridine as functional groups. And it can be reacted with hydrochloric acid to form its hydrochloride salt. The polystyrylpyridines are highly thermostable and thermosetting resins, resulting from the polycondensation of dimethyl pyridine derivatives and aromatic dialdehydes. Their main characteristics are their easy processability and high heat resistance. So, their composite materials have good mechanical behavior, especially at high temperatures.
Alkyl Halides and Substitution Reactions
Published in Michael B. Smith, A Q&A Approach to Organic Chemistry, 2020
When an amine base (triethylamine, NEt3) is added to this reaction, pentan-2S-ol reacts with thionyl chloride to give a sulfinate ester and HCl. In this reaction, the added amine, which is a base, reacts with HCl to form triethylammonium hydrochloride, so there is a nucleophilic chloride in the reaction medium. Rather than an intramolecular decomposition leading to (2S)-chloropentane, the sulfinate ester reacts with the chloride ion intermolecularly to give (2R)-chloropentane by a SN2 reaction. The product is (2R)-chloropentane, which is the result of backside attack of the chloride ion and inversion of configuration.
Composition of Proprietary Products Approved in the United States
Published in Sarfaraz K. Niazi, Handbook of Pharmaceutical Manufacturing Formulations, Third Edition, 2019
EVISTA® (raloxifene hydrochloride) tablets contain 60 mg of raloxifene HCl, which is the molar equivalent of 55.71 mg of free base. Inactive ingredients include anhydrous lactose, carnauba wax, crospovidone, FD&C Blue No. 2 Aluminum Lake, hypromellose, lactose monohydrate, magnesium stearate, modified pharmaceutical glaze, polyethylene glycol, polysorbate 80, povidone, propylene glycol, and titanium dioxide.
Production of stable amorphous form by means of spray drying
Published in Particulate Science and Technology, 2019
Igor Nežić, Aleksandra Sander, Ernest Meštrović, Dražen Čavužić
5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide is an API of a drug, antidepressant agent, developed by Forest Laboratories Inc. (licensed from Merck) under the brand name VIIBRYDTM as a dual-acting and selective serotonin-reuptake inhibitor and 5-HT1A receptor partial agonist for treatment of major depressive disorder (Figure 1). Active substance is present in the form of hydrochloride salt.