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Melt Extruded Amorphous Solid Dispersions
Published in Isaac Ghebre-Sellassie, Charles Martin, Feng Zhang, James DiNunzio, Pharmaceutical Extrusion Technology, 2018
Pinak Khatri, Dipen Desai, Harpreet Sandhu, Atsawin Thongsukmak, Gaurang Patel, Jaydeep Vaghashiya, Wantanee Phuapradit, Navnit Shah
Albano et al. (2012) demonstrated that the incorporation of docusate sodium in melt extruded solid dispersion helped improve dissolution rate and reduce motor load and process temperatures (Albano et al., 2012). On the other hand, Janssens et al. (2008) have shown that the addition of even 10% of TPGS 1000 to the polyvinyl pyrrolidone co-vinyl acetate (PVPVA) 64 carrier matrix causes destabilization of the molecular dispersion of itraconazole and leads to the formation of crystalline itraconazole clusters. Therefore, the choice and concentration of surfactant should be judiciously selected by considering their effect on processing conditions, solid-state physical stability, and the physical stability of amorphous solid dispersions during exposure to in vitro dissolution media or gastrointestinal fluid.
Composition of Proprietary Products Approved in the United States
Published in Sarfaraz K. Niazi, Handbook of Pharmaceutical Manufacturing Formulations, Third Edition, 2019
Peri-Colace® (docusate sodium and standardized senna concentrate) is a combination stimulant laxative and stool softener. Peri-Colace® tablets contains the following active ingredients: 50 mg of docusate sodium and 8.6 mg of sennosides. Inactive ingredients: carnauba wax, colloidal silicon dioxide, croscarmellose sodium, dicalcium phosphate, FD&C Blue No. 2, FD&C Red No. 40, hypromellose, magnesium stearate, microcrystalline cellulose, PEG 400, sodium benzoate, stearic acid, and titanium dioxide.
Synthesis and investigation of halogen-free phosphonium-based ionic liquids for lubrication applications
Published in Tribology Transactions, 2019
Lili Zhu, Jun Dong, Ying Ma, Yulong Jia, Cheng Peng, Weimin Li, Ming Zhang, Kuiliang Gong, Xiaobo Wang
Accordingly, developing environmentally friendly ILs from renewable and biodegradable resources to diminish or avoid corrosion and toxicity has becoming an inevitable strategy. Numerous halogen-free ILs such as saccharin (Kumar, et al. (23); Hough-Troutman, et al. (24)), amino acid (Liu, et al. (25); He, et al. (26)), and ibuprofen (Viciosa, et al. (27); Sintra, et al. (28)) ILs have been designed and synthesized to replace traditional corrosive or hazardous ILs. Unfortunately, these ILs presented very poor thermal stability in many cases (Reeves, et al. (29); Howell, et al. (30); Liu, et al. (31)). Indeed, the physicochemical properties and nontoxicity of ILs can be regulated and customized by building precursor units from active pharmaceutical ingredients and biomass due to their biodegradability and hypotoxicity (Hough, et al. (32); Zhao, et al. (33); Rogers and Seddon (34)). Sodium docusate (also called dioctyl sodium sulfosuccinate) is known as a common surfactant found in over-the-counter laxative stool softeners. It is also utilized in the pharmaceutical manufacturing industry as an emollient or wetting or dispersing agent (Smith, et al. (35); Rosal, et al. (36); Bai, et al. (37)). Recently, it was verified in the literature that phosphonate ILs usually tend to have good thermal stability (Fan, et al. (38); Battez, et al. (39); Shah, et al. (40)). Inspired by these surveys, great efforts have been devoted to searching for new halogen-free ILs as lubricants to enhance triboperformance, particularly for steel–steel contacts.