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Potentialities of Medicinal Plant Extracts Against Biofilm-Forming Bacteria
Published in Bakrudeen Ali Ahmed Abdul, Microbial Biofilms, 2020
Muhammad Bilal, Hira Munir, Hafiz M. N. Iqbal
Coumarins are derivatives that occur naturally in a wide range of biological functionalities such as vasodilatation, photosensitizing, antimicrobial, antibiofilm, and anti-inflammatory activities (Kalkhambkar et al., 2008). Lee et al. (2014b) documented that umbelliferone and coumarin showed potential activity against the development of biofilm formation by E. coli O157:H7. The biofilm-forming ability of E. coli has been reported to inhibit the use of coladonin (Lee et al., 2014b). Coumarins including esculin, esculetin, nodakenetin, and psoralen also result in the suppression of biofilm development of P. aeruginosa (Durig et al., 2010; Ding et al., 2011). Xanthohumol is a prenylated chalconoid that inhibits the adhesion and biofilm construction of S. aureus. It also leads to the inactivation of bacterial isolates in preformed biofilm due to destructing the integrity of the cytoplasmic membrane of the bacteria by inhibiting the lipid metabolism (Rozalski et al., 2013).
Polyphenol Nanoformulations for Cancer Therapy: Role of Milk Components
Published in Lohith Kumar Dasarahally-Huligowda, Megh R. Goyal, Hafiz Ansar Rasul Suleria, Nanotechnology Applications in Dairy Science, 2019
Coumarins are benzopyrone analogs with wide range on biological properties such as antioxidant, anticancer, vasorelaxant, antiviral, and anti-inflammatory.47 Umbelliprenin (7-farnesyloxy-coumarin), synthesized by Ferula plant species, has shown anticancer activity in different cancer cells lines (metastatic pigmented malignant melanoma, non-small cell lung carcinoma), and in mouse skin tumor model. It showed inhibitory effects on the activity of matrix metalloproteinases, which play critical roles in cancer metastatic cascade, such as migration, angiogenesis, and invasiveness. Nanoencapsulated formulation of coumarin and its analogs showed mixed activity.
A DFT investigation of the influence of α,β unsaturation in chemical reactivity of coumarin and some hydroxy coumarins
Published in Tanmoy Chakraborty, Prabhat Ranjan, Anand Pandey, Computational Chemistry Methodology in Structural Biology and Materials Sciences, 2017
M. A. Jaseela, T. M. Suhara, K. Muraleedharan
In chemical aspects, Coumarin is a member of benzopyrone family, all of which are consisting of benzene ring joined with α-pyrone ring. Benzopyrones are further classified into two categories of benzo-α-pyrone to which Coumarins belong and benzo-γ-pyrone of which flavanoids are the principal candidates. The Coumarins are of great interest due to their tremendous pharmacological properties and characteristic conjugated molecular architecture [25]. The basic structure of Coumarin is as given in Figure 2.1.
An efficient one-pot four-component Gewald reaction: Synthesis of substituted 2-aminothiophenes with coumarin–thiazole scaffolds under environmentally benign conditions
Published in Journal of Sulfur Chemistry, 2019
Kotthireddy Kavitha, Devulapally Srikrishna, Pramod Kumar Dubey, Pasula Aparna
Coumarin is a phytochemical that can be extracted from plants and microorganism natural sources. It was studied extensively due to its distinct applications in the field of synthetic organic chemistry, pharmacology, materials chemistry, and agrochemistry. Coumarin and its derivatives are the constituents of commercially available medicines namely fraxetin and esculetin which are known to exhibit anti-inflammatory and anti-oxidant activities, respectively [1]. They exhibit diverse pharmacological properties in particular anti-tumor [2], anti-diabetic [3], anti-microbial [4], and anti-thrombotic activities [5]. In addition to coumarins, thiazoles and its derivatives also have a significant role in the field of medicinal chemistry where they found to exhibit a wide variety of activities such as anti-tumor [6–8], anti-microbial [9], anti-convulsant [10], and anti-inflammatory activities [11].
Coumarin-naphthohydrazone ligand with a rare coordination mode to form Mn(II) and Co(II) 1-D coordination polymers: synthesis, characterization, and crystal structure
Published in Journal of Coordination Chemistry, 2018
Rahman Bikas, Hossein Farzaneh-Bonab, Nader Noshiranzadeh, Muhittin Aygün, Marzieh Emami, Tadeusz Lis
Coumarin (Scheme 2(a)) is a fragrant organic compound in the benzopyrone chemical class found in many plants [15]. Coumarin derivatives can be easily prepared by reactions like the Perkin reaction [16] or the Pechmann condensation [17]. Coumarin compounds display important biological activities such as antimicrobial, antifungal, anticoagulant, anti-HIV, anticancer, and antioxidant properties and have been widely used in perfumes and fabric conditioners [18]. They are also used in some dye lasers and as a sensitizer in photovoltaic technologies [19]. More specifically, 3-acetylcoumarins (Scheme 2(b)) can be useful in coordination chemistry since it has acetyl functionality which can be involved in Schiff base condensation with primary amines to form interesting ligands. In general, it can coordinate similar to ligands derived from ortho-hydroxy aldehydes/ketones (Scheme 2(c)). However, the oxygen in this case coordinates to metal ions as a neutral O-donor (Scheme 2(d)). Therefore, such ligands will have moderate negative character and may be safer than salicylalidine derivatives by considering their occurrence in several biological systems and applications in various environments.
Unsymmetrical Coumarin based dimeric liquid crystals: Synthesis, Characterization, Mesomorphic investigation, Photoluminescence and Thermal conductivity
Published in Liquid Crystals, 2022
AbdulKarim-Talaq Mohammad, Hind Khalid Mustafa
“Coumarins” are an organic heterocyclic, a group of naturally occurring lactones and their nucleus is represented by benzo-α-pyrone (2 H-1-benzopiran-2-one). Based on its chemical diversity and complexity, natural coumarin is categorised into different classes such as simple coumarin, isocoumarins, furanocoumarins, angular, linear pyranocoumarins, biscoumarins, and phenylcoumarins [1]. Coumarin is a common secondary metabolite found naturally in many plant species [2], including those of the families Clusiaceae, Umbelliferae, Rutaceae and Leguminosae [3,4], and essential oils, therefore it has been used in food and cosmetic products as a fragrance [2].