4-aminopyridine

4-aminopyridine

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Published in T.S.S. Dikshith, and Safety, 2016

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks the potassium channels in neurons. It should be borne in mind that this is an experimental drug and its side effects are uncertain. Dosages should be carefully regulated, as potassium is a chemical that is used extensively in other parts of the body, including heart functions.

Co-crystallisation of 4-amino pyridine with succinic acid (1:1): spectroscopic, thermal, crystal structure, DFT/HF calculation and Hirshfeld surface analysis

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Published in Molecular Physics, 2022

P. J. Srijana, Mulveer Singh, B. Narayana, B. K. Sarojini, U. Likhitha, Rajni Kant

Aminopyridines are N-heterocyclic amines with anti-bacterial and antithrombotic properties that have been used to treat various types of diseases [9]. In particular, 4-aminopyridine is the first drug molecule that is particularly used in the treatment of multiple sclerosis syndromes by blocking the potassium channel [10]. It has two hydrogen bond donors and two hydrogen bond acceptors, while in cationic form; it has three hydrogen bond donors. In general, 4-aminopyridine forms complexes with carboxylic acid, resulting in supra-molecular heterosynthon by establishing either neutral N–H···O or N+–H···O− hydrogen bonds. There are various reports in the literature on co-crystals and salts of 4-aminopyridine [11–16].

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Co-crystallisation of 4-amino pyridine with succinic acid (1:1): spectroscopic, thermal, crystal structure, DFT/HF calculation and Hirshfeld surface analysis