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Additive manufacturing in the craniofacial area
Published in Ali Khademhosseini, Gulden Camci-Unal, 3D Bioprinting in Regenerative Engineering, 2018
Cedryck Vaquette, Kelly McGowan, Saso Ivanovski
As a variation to established clinical procedures, Le et al. [40] demonstrated a tent-pole grafting technique, where titanium screws were strategically placed in the alveolar bone leaving 5–7 mm of screw threads exposed above the ridge. Demineralized allograft was used to cover the screw completely, then a resorbable membrane was placed over the grafted sites as shown in Figure 12.1e. Although it achieved sufficient bone augmentation to allow implant placement, it required release of the mylohyoid muscle from its attachment in the mandible and a split-thickness flap labially to avoid damage to the mental nerve. In all maxillary cases, the periosteal flaps were released from the nasal spine and scored to allow tension-free closure. The authors report that these additional methods are critical to avoid wound dehiscence and subsequent graft exposure.
A systematic review of follow-up results of additively manufactured customized implants for the pelvic area
Published in Expert Review of Medical Devices, 2023
Jeffrey Zoltan, Diana Popescu, Seyed Hamid Reza Sanei
Several of the articles made note of wound dehiscence and additional healing complications encountered, with some going on to infection [11,31,39–43]. There were, however, no control groups in these articles. Inherently, the patient populations in these complex tumor cases will incur a higher wound healing complication rate, and it would not necessarily be implant-dependent. Attributing these wound healing complications to the AM implants would require a control group without which no conclusion can be made. There were other complications worthy of mention, but also difficult to attribute to the AM implant. Most notably, hip dislocations did occur, although not related to implant failure. For instance, Durand-Hill et al. [44] did note one case of fixation failure, which was in conjunction with a periprosthetic native iliac crest fracture. It is unclear whether the complication occurred intra-operatively or post-operatively, but was revealed on subsequent imaging after the patient suspected component migration following ambulation. The remaining studies in Table 1 found no documented instances of any implant failure at follow-up. Moreover, these were not noted in any comparison studies that would attribute these complications to the implant itself. What’s more, hip stability in general has many factors surrounding the pelvis, including soft tissue balancing, and even outside of the pelvis, including lumbosacral pathology, which can play a major role in hip stability. These variables were not accounted for in these studies.
Synthesis of Moringa oleifera coated silver-containing nanocomposites of a new methacrylate polymer having pendant fluoroarylketone by hydrothermal technique and investigation of thermal, optical, dielectric and biological properties
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Ibrahim Erol, Ibrahim Hakkı Cigerci, Arzu Özkara, Dilek Akyıl, Mecit Aksu
The effect of PFPAMA and PFPAMA/MAg nanocomposites on cell migration in wound healing was investigated by cell culture studies. For this purpose, the scratch wound assay test was performed [37]. For this, human umbilical vein endothelial cells (HUVECs) were used in RPMI 1640 (GIBCO, Uxbridge, UK) medium containing 10% fetal bovine serum (HyClone, Logan, UT, USA) with a cell density of 35 mm (1 × 106 cells/mL) cultured in a flask. Inactivated at 45 °C for 1 h, 100 U/mL penicillin and 100 µg/mL streptomycin (Sigma, St. Louis, MO, USA) were incubated at 37 °C in a humidified atmosphere with 5% CO2, and the cells were above the ground. It is allowed to cover 100%. In wound healing experiments, voids are created on the cell layer in a culture dish containing a single layer of cells with 100% floor coverage. Thus, it is observed that the cells at the wound borders fill the wound. Then, using a sterile micropipette tip, three parallel cell-free wounds were opened on the cell layer. The medium was changed twice, and the cells floating in the medium were removed during the wound dehiscence. Cells were incubated for 24 h in an oven containing 5% CO2 at 37 °C for closure of the wounds by cell migration. The effects of PFPAMA-MAg nanocomposites on wound healing were measured 24 h after injury. Wound healing for Huvecs was observed with a live cell imaging system.
Medical textiles
Published in Textile Progress, 2020
In plastic surgery, the most common wound complications are tissue reactivity, infections and wound dehiscence. It is well known that choice of suture material is imperative to appropriate wound closure. The ‘perfect’ suture material should be of uniform calibre (possess uniform linear density), be readily available, be reasonably inexpensive and easy to sterilize, elastic, supple and have good tensile strength. In one study of 1000 plastic surgical wounds [322], the wounds were evaluated at days 3, 7 and 14 post operation for three outcomes of interest: tissue reactivity, wound dehiscence and local infection. Monofilament non-absorbable sutures used in the study included nylon. Multifilament absorbable sutures of catgut, polglycolic acid and polyglactin (a copolymer of glycolic and lactic acid) were used. Multifilament non-absorbable synthetic sutures of braided polyamide and polyester and natural sutures of silk were used.