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Aromatic Medicine
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Sakshi Bajaj, Himangini Bansal
Melaleuca alternifolia (tea tree) oil tried positive for its all constituents for in vitro antifungal activity but beta-myrcene. Hammer et al. recognized that the majority of the components of tea tree oil had wide scope of fungicidal potential, particularly against dermatophytes and filamentous organisms (Hammer et al., 2003). Elshafie et al. assessed the antifungal effect of the single segments of O. vulgare EO (carvacrol, thymol, linalool, and transcaryophyllene) against the postharvest pathogens M. laxa, M. fructigena, and M. fructicola. The fungicidal activity assay of the over four single components has been done in vitro.
Development of nanoemulsion gel based formulation of terbinafine for the synergistic antifungal activity: Dermatokinetic experiment for investigation of epidermal terbinafine deposition enhancement
Published in Inorganic and Nano-Metal Chemistry, 2021
Prabhu Raut, Shobhit Kumar, Babar Iqbal, Javed Ali, Sanjula Baboota
Tea tree oil consists of terpenes and lipoid substance along with complex mixture of volatile oil and has been used in the preparation of nanoemulsions as it has antifungal activity. Tea tree oil is extracted from leaves of the plant Melaleuca alternifolia.[5] The cycloolefins and enol compounds (terpinen-4-ol, α-terpineol, α and γ terpinene, and 1,8-cineole) are the major constituents of tea tree oil.[6] It shows wide variety of pharmacological activity such as antibacterial, antioxidant, anti-inflammatory, anti-fungal, anti-carcinogenicity, and immune regulatory effects.[5] Several researchers have reported that tea tree oil shows antifungal activity by altering membrane fluidity of C. albicans cells as well as by inhibiting glucose-induced medium acidification.[7] Thus, in the present study tea tree oil provides two benefits, i.e., firstly it acts as an oil phase and secondly, it provides synergistic antifungal activity along with terbinafine for the treatment of fungal infections.