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Molecular determinants of TRPC6 channel recognition by FKBP12
Published in Tanmoy Chakraborty, Prabhat Ranjan, Anand Pandey, Computational Chemistry Methodology in Structural Biology and Materials Sciences, 2017
Peng Tao, John C. Hackett, Ju Young Kim, David Saffen, Carrigan J. Hayes, Christopher M. Hadad
Native TRPC channels comprise four protein subunits, which are symmetrically organized around a central pore. Each subunit contains six transmembrane (TM) domains and a single membrane-loop domain (located between TM5 and TM6) that contributes to the channel pore. The aminoand carboxyl-termini of each subunit are located on the intracellular side of the membrane. TRPC3, TRPC6 and TRPC7 channels are structurally and functionally related and constitute a subfamily of TRPC channels [7,8]. Each of these subtypes can form homotetrameric channels or combine with other subfamily members to form heterotetrameric channels.
Influence of microcystins-LR (MC-LR) on autophagy in human neuroblastoma SK-N-SH cells
Published in Journal of Toxicology and Environmental Health, Part A, 2019
Yue Yang, Cong Wen, Shuilin Zheng, Wenya Liu, Jihua Chen, Xiangling Feng, Xiaoyan Wang, Fei Yang, Zhen Ding
Ca2+ is a key element involved in numerous cellular processes. It is believed that autophagy is regulated by a variety of factors including Ca2+ (Fedeli et al. 2019), calpain (Ong et al. 2019) and reactive oxygen species (ROS) (Park and Chung 2019). Li et al. (2019) noted that silver nanoparticles induced protective autophagy via activation of Ca/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells. Ji et al. (2018) demonstrated that TRPC6-mediated Ca2+ signaling was associated with hypoxia-induced autophagy in human kidney podocytes. Our data showed both concentrations of MC-LR increased the concentration of intracellular free calcium ions. Evidence indicates that alterations in intracellular calcium concentrations may be associated with MC-LR-initiated neuronal SK-N-SH cells autophagy.