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Rosmarinic Acid: A Boon in the Management of Cardiovascular Disease
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand, Chowdhury Mobaswar Hossain, Imran Kazmi, Sanmoy Karmakar
Acute myocardial infarction (AMI) and arrhythmia are a menace to the society and a great cause of hospitalization and mortality respectively. The cellular calcium level is regulated by both Sarcoplasmic reticulum Ca2+ ATPase (SERCA2) and Ryanodine receptor (RyR2), respectively. The protocol was designed in such a way so as to investigate whether rosmarinic acid can safeguard cardiac functions against AMI and arrhythmia induced by Isoproterenol, modulated by both SERCA2 and RyR2 genotypically. For mechanism of rosmarinic acid in myocardial infarction refer to Figure 10.1 (Javidanpour et al., 2018).
MicroRNA-98 is a prognostic factor for asbestos-induced mesothelioma
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Kihun Kim, Yeji Ko, Hyeoncheol Oh, Mihyang Ha, Junho Kang, Eun Jung Kwon, Ji Wan Kang, Youngjoo Kim, Hye Jin Heo, Guanghwi Kim, Jung Won Kim, Yun Hak Kim
The current molecular studies on MPM demonstrated that specific genes such as p14ARF, p16INK4, and NF2-MERLIN are key elements involve in pathogenesis (Schipper et al. 2003; Wong et al. 2002; Yang et al. 2000). Robinson and Lake (2005) noted that these genes inhibited tumor growth. In addition, genetic alterations in set domain containing 2 (SETD2), DDX3X, unc-like autophagy activating kinase (ULK2), ryanodine receptor 2 (RR2), cilia, and flagella associated protein 45 (CFAP45), set domain bifurcated 1 (SETDB1), and DDX51 were examined in MPM (Bibby et al. 2016). While miRNAs play an important role in the development of several cancers, only a few reports discuss their role in MPM development and progression (De Santi et al. 2017). Recently De Santi et al. (2017) conducted miRNAs analysis of genes associated with deregulation such as CDKN2A, NF2, JUN, HGF, and PDGFA. Some miRNAs were found to be up-regulated (miR-101, miR-25, miR-26b, miR-335, and miR-223) or down-regulated (miR-29, miR216) in MPM. Lamberti et al. (2015) proposed these as clinical biomarkers. Further, four miRNAs (miR-16, miR-1, miR-145, and miR-223) were reported to be down-regulated in frozen MPM tissue (Martínez-Rivera et al. 2018). In addition, overexpressed exosomal miR-16-5p was found to induce MPM suppression (Munson et al. 2019).