Explore chapters and articles related to this topic
Toxic Organizations
Published in Ronald J. Burke, Cary L. Cooper, Risky Business, 2016
Ronald J. Burke, Cary L. Cooper
PTSD was initially addressed using psychological treatment. However, an increasing number of researchers now view PTSD as having a psychobiological function, suggesting that medication may reduce PTSD symptoms. Stein, Ipser, and Seedat (2006) undertook a review of 35 short-term randomized controlled trials of pharmacotherapy for the treatment of PTSD symptoms involving 4,597 participants. They found that a larger proportion of patients responded to medication than to a placebo (13 trials, 2,507 participants. In addition, symptom severity was significantly reduced in 17 trials (2,507 participants). The most promising medication was selective serotonin reuptake inhibitors (SSRIs). Stein, Ipser, and Seedat suggest that long-term medication may be needed in treating PTSD.
Centella asiatica L. Urban protects against morphological aberrations induced by chronic unpredictable mild stress in rat’s hippocampus via attenuation of oxidative stress
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Saravanan Jagadeesan, Samaila Musa Chiroma, Mohamad Aris Mohd Moklas, Mohamad Taufik Hidayat Baharuldin, Che Norma Mat Taib, Zulkhairi Amom, Thirupathirao Vishnumukkala, Warren Thomas, Onesimus Mahdi
The current drug treatment for depression is based on selective serotonin reuptake inhibitors (SSRI’s), monoamine oxidase inhibitors (MAOI’s), and tricyclic antidepressants (TCA’s). These treatments have significantly contributed to enhancing the quality of life of individuals with depression, but they are not without their limitations. The current medications do not produce a uniform response among patients, it takes weeks for their effects to be observed and many treatments have significant side effects [16]. The concurrent use of multiple drugs complicates the problems through complex interactions and in particular gives rise to uncertainty regarding their safe use in pregnancy [17]. Fluoxetine is a commonly used antidepressant, and as an SSRI, it inhibits the serotonin transporters at the synaptic cleft. Though in wide use, fluoxetine has side effects including fatigue, weight gain, and sexual dysfunction [18,19]. Thus, though there is a wide range of medications available for the treatment of depression, none of them are universally effective or without side effects. Consequently, there is a need for new therapeutic agents with lesser side effects and broader efficacy [20]. In order to achieve this, it is necessary to consider the critical physiological processes that contribute to stress and depression.