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H-Imidazoles via Multi-Component Reactions and Its Medicinal Importance
Published in Satish A. Dake, Ravindra S. Shinde, Suresh C. Ameta, A. K. Haghi, Green Chemistry and Sustainable Technology, 2020
2,4,5-Triaryl-1H-imidazole compounds have gained the remarkable importance due to their widespread biological activities and their use in synthetic chemistry. The substituted imidazoles are well known as inhibitors of P38MAP kinase [1] and therapeutic agents [2]. Imidazole chemistry, because of its use in ionic liquids (ILs) [3] and in N-heterocyclic carbenes (NHCs) [4], gave a new dimension in the area of organometallics and “Green Chemistry.” Moreover, the imidazole ring system is one of the most important substructures found in a large number of natural products and pharmacologically active compounds such as the hypnotic agent etomidate [5] and the proton pump inhibitor omeprazole A [6], trifenagrel [7] B is a 2,4,5-triaryl-1H-imidazole that reduces platelet aggregation in several animal species and humans (Scheme 9.1).
Compressed Solids Formulations
Published in Sarfaraz K. Niazi, Handbook of Pharmaceutical Manufacturing Formulations, Third Edition, 2019
Compress the resulting mixture is compressed into tablets on a standard tablet press with average weight of about 1.5 g that contain about 20 mg omeprazole. These tablets should have low friability and rapid disintegration time. This formulation may be dissolved in an aqueous solution containing a buffering agent for immediate oral administration. Alternatively, the suspension tablet may be swallowed whole with a solution of buffering agent. In both cases, the preferred solution is sodium bicarbonate 8.4%. As a further alternative, sodium bicarbonate powder (about 975 mg per 20 mg dose of omeprazole or an equipotent amount of other proton pump inhibitor [PPI]) is compounded directly into the tablet. Such tablets are then dissolved in water or sodium bicarbonate 8.4%, or swallowed whole with an aqueous diluent.
An Introduction to Risk Assessment with a Nod to History
Published in Ted W. Simon, Environmental Risk Assessment, 2019
Biomarkers of effect measure some physiological variable that is altered or affected by exposure. For example, consumption of indole-3-carbinol found in broccoli, the use of the pharmaceutical proton pump inhibitor omeprazole, and exposure to the dioxin-like chemicals all increase the activity of CYP1A2, the liver enzyme that metabolizes caffeine.197,198 This enzyme activity can be measured using exhaled breath or urinalysis.
Analytical and electroanalytical techniques in the determination of (Fe+2) results from iron corrosion: effect of omeprazole drugs as green inhibitors
Published in Green Chemistry Letters and Reviews, 2021
The survey of literature reveals that omeprazole drug belongs to a group of medicines called proton-pump inhibitor (PPI); it is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. It can be taken orally or injected into a vein (37). Omeprazole contains oxygen, nitrogen and sulfur heteroatoms in addition to active substituted aromatic groups and a tri-coordinated sulfinyl sulfur in a pyramidal structure, as shown in Figure 1. So the use of Omeprazole ampules as green corrosion inhibitors gives promise.
World Trade Center Health Program best practices for the diagnosis and treatment of gastroesophageal reflux disease
Published in Archives of Environmental & Occupational Health, 2023
Ruth A. Lin, Geoffrey M. Calvert, Iris G. Udasin
Switching to a different PPI can be considered for patients who experience minor PPI side effects including headaches, abdominal pain, nausea, vomiting, abdominal pain, diarrhea and flatulence. For patients with GERD taking clopidogrel and who also have LA grade C or D esophagitis, the established benefits of PPI outweigh the risks. For patients with renal failure taking PPI, close monitoring or consultation with a nephrologist is indicated.