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paniculata (C.B. Clarke) Munir Leaves on Various Gastric Aggressive Factors
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
P. S. Sreeja, K. Arunachalam, Parimelazhagan Thangaraj
There are different types of ulcers that occur inside and outside the body, such as peptic, stomach, corneal, foot, or leg ulcers, etc. Peptic ulcers are in the lesions/cavities in the mucosal layer and are surrounded by inflammation; they are caused by the imbalance between the protective and aggressive factors in the stomach and duodenum. They are mainly of two types: gastric and duodenum (Singh et al. 2018).
Herbal Therapies
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
H. Shahrul, M. L. Tan, A. H. Auni, S. R. Nur, S. M. N. Nurul
Another condition which is treated with herbs is peptic ulcer, it is a major GI disorder that occurs due to an imbalance in mucosal offensive (gastric acid secretion) and defensive (gastric mucosal integrity) factors (Umukoro and Ashorobi, 2006). Among the factors causing peptic ulcer are Helicobacter pylori infection, smoking, drinking alcohol, and chronic ingestion of drugs (Zhang et al., 2010).
Antioxidant potentialities and gastroprotective effect of Reichardia picroides extracts on Ethanol/HCl induced gastric ulcer rats
Published in International Journal of Environmental Health Research, 2023
Samia Oueslati, Raja Serairi Beji, Feten Zar Kalai, Merieme Soufiani, Walid Zorrig, Salama Aissam, Kamel Msaada, Cherkaoui El Modafar
However, after literature examination, it appears that there are no available reports on both antioxidant activity and gastroprotective effects of Tunisian R. picroides. In fact, peptic ulcer disease continues to be a source of significant morbidity and mortality worldwide (Boeing et al. 2021) and it affects nearly 8% to 10% of the world’s population and requires an efficient and potent therapeutic approach (Vasudeva et al. 2012). In general, gastric ulcer expands during an imbalance between protective and aggressive factors of the gastric mucosa. Presently, peptic ulcers are treated with H+-receptor blockers (such as famotidine), cytoprotectants and proton pump inhibitors, which reduce and/or inhibit the morbidity rates but are probably associated with adverse effects (Yuan et al. 2006). Additionally, secondary metabolites have shown therapeutic benefits against gastric damage without adverse effects (Koc et al. 2020).
Anti-ulcerogenic effect of methanol fraction of Ocimum gratissimum leaves extract and honey on indomethacin-induced gastric ulcer in rats
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Aanuoluwa James Salemcity, Blessing Oluwagbamila Omolaso, Oghenefega Sheila Ogegere, Victoria Olasumbo Oluokun
Peptic ulcer is an injury found in the gastro-intestinal tract as a result of the corrosion of the mucosal lining in response to the influence of excessive acidity, Helicobacter pylori, reduced bicarbonate reserve, prostaglandin synthesis, and even compromise in the microflora of the intestine [1]. This disease occurs from the compromise in the defense mechanisms of this tract [1]. It can also ensue from the cleavage activity of pepsin on the stomach, thus exerting its function on gastric and duodenum domains elongating via muscularis mucosae. This position of effect determines the names it is called, either duodenal or gastric ulceration [2].
A novel fuzzy expert system design to assist with peptic ulcer disease diagnosis
Published in Cogent Engineering, 2021
Saeedreza Arab, Kianaz Rezaee, Ghazaleh Moghaddam
A peptic ulcer is one of the essential diagnosis concerns (Lanas & Chan, 2017). Peptic ulcer illness involving duodenal and gastric ulcer is the most common gastrointestinal disorderliness (Laine & Peterson, 1994; Umashanker & Shruti, 2011). A peptic ulcer is a lesion in the lining mucosa of the digestive tract, typically in the stomach or duodenum. It is caused by the digestive action of pepsin and stomach acid. Different factors such as Helicobacter pylori can cause gastrointestinal ulcers (Fashner & Gitu, 2015). Helicobacter pylori is a type of bacteria that can cause stomach infections and inflammation (Malfertheiner et al., 2017). Gastroenterologists decide based on diagnostic, therapeutic and monitoring problems (Quinlan, 1986). In health-care procedures diagnostic part is started by evaluating clinical data from physical examination and patient history. The diagnostic hypotheses given at this level are refined and ultimately confirmed with more information in the following part. Disease classes are defined as erosive gastritis, gastro-oesophagealreflux, chronic antral gastritis, and peptic ulcer (Umashanker & Shruti, 2011). Frequent use of drugs, smoking, alcohol, radiation therapy, and gastric cancer are among other causes of ulcers (Ramakrishnan & Salinas, 2007). Furthermore, it is important to note that suggested pharmaceutical products for gastric ulcers are not occasionally effective. To the best of our knowledge, numerous unfavorable symptoms are reported as a result of using them. Nowadays, the focus on herbal studies represents a high potential application of medicinal herbs in this field (Pena-Reyes & Sipper, 1999). It is valuable to diagnose disease according to the symptoms at an early stage to treat by either chemical or herbal medications.