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The Use of Capillaroscopy and Aggregometry Methods to Diagnose the Alterations of Microcirculation and Microrheology in Diabetes
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Andrei E. Lugovtsov, Yury I. Gurfinkel, Petr B. Ermolinskiy, Anastasia A. Fabrichnova, Alexander V. Priezzhev
There is sufficient evidence indicating that increased blood viscosity is a pathogenetic factor in the development of diabetic microangiopathy, microcirculation disorders, and reduced tissue perfusion in DM [19]. Increasing blood viscosity may also be particularly important in the etiology of diabetic retinopathy [15,20,21]. The development of diabetic angiopathy has been shown to be associated with abnormalities in hematocrit, plasma viscosity, and RBC aggregation [22,23] and reduced deformity of RBCs [24,25]. Thus, patients suffering from DM have a higher blood viscosity than people without DM [25].
Fagonia indica ameliorates chromium-induced nephrotoxicity: Role of antioxidant activity and pro-inflammatory cytokines in in-vivo renoprotection
Published in Archives of Environmental & Occupational Health, 2023
Eman A. A. Abdallah, Abdullah Almilaibary, Mohamed F. El-Refaei
Nephrotoxicity is the term used to describe a significant reduction in kidney function caused by the toxic effects of medicines and other substances, and it can occur due to different factors, including crystal nephropathy, thrombotic microangiopathy, inflammation, and renal tubular toxicity.45,46 Cr is recorded as the most toxic and hazardous metal ion found in soil and water. Mostly, Cr toxicity is caused by oxidative stress, which results in the creation of ROS in the cells, negatively altering the cellular signaling pathways and consequently inducing mitochondrial dysfunction due to the rapid activation of NF-κB, STAT3, and other proteins that encourage gene expression during an inflammatory response.47 Clinical studies show that stomach cancer among workers (gold miners) was caused by Cr oral toxicity in some individuals.48 Furthermore, women who worked in Cr plating are confronting acute hepatitis with jaundice and exhibiting mild to moderate liver complications.49