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Noninvasive Photonic Sensing of Glucose in Bloodstream
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Microcirculation plays an important role in several vital functions, such as regulation of blood pressure, metabolic exchanges, homeostasis of interstitial fluids, and thermoregulation, to ensure proper tissue nutrition. Therefore, monitoring the distribution of blood between nutritional and non-nutritional skin microvessels remotely and continuously may be an early indication of diabetic foot.
Effects of continuous and pulsatile flows generated by ventricular assist devices on renal function and pathology
Published in Expert Review of Medical Devices, 2018
Takuma Miyamoto, Jamshid H. Karimov, Kiyotaka Fukamachi
Orime et al. [7] induced acute HF in pigs by ligating the left anterior descending artery; the animals were then supported by PF LVAD or centrifugal CF LVAD. Organ microcirculation was estimated by using laser regional blood flowmeters. Pigs under PF LVAD support showed significant improvement in microcirculation recovery in the renal cortex but not the renal medulla compared with those on CF LVAD support. A similar study in pigs was reported by Sezai et al. [8]. The investigators connected either a PF pump or a CF pump from the left atrium to the ascending aorta. The left anterior descending arteries were ligated to induce acute HF; then the pigs were assisted by either pump. There was no difference between groups regarding mean aortic pressure or total flow. In the PF group, microcirculation increased in the renal cortex, but in the CF group, microcirculation decreased after 6 h of support. Additionally, renal arterial blood flow, concentration of β2-microglobulin, and urine output were significantly lower in the CF group. In these experiments, the investigators successfully showed the superiority of PF support on the recovery of kidneys from acute ischemic damage in acute settings.