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Toxicity of Solvents
Published in Lorris G. Cockerham, Barbara S. Shane, Basic Environmental Toxicology, 2019
Acute exposure to methyl alcohol results in depression of the CNS. The symptoms include headache, vertigo, severe upper abdominal pain, blurred vision, bradycardia, slow shallow breathing, coma, and death (Harger and Forney, 1967). Visual disturbances, for example, blurring and loss of acuity, are characteristics of methanol poisoning. The effect upon the eyes has been attributed to optic neuritis which regresses. However, if the optic nerve atrophies, permanent blindness will result.
The effect of nitrogen concentration on N-doped diamond-like carbon films prepared by plasma-electrolytic method
Published in Inorganic and Nano-Metal Chemistry, 2021
S. Sarihi, S. Padervand, S. M. Mousavi khoei, N. Shakiba
According to studies, the improved hardness of diamond-like carbon films is always accompanied by high internal compressive stress limiting their applications. Franceschini et al.[33] investigated the effect of N-doped DLC coatings on mechanical properties the substrates. They found that the internal compressive stress was reduced substantially, while the mechanical hardness did not change considerably. Furthermore, it has been found that, unlike diamond films, the N-doped films by its atomically flat surface, can be deposited on many substrates at ambient temperature. The N-doped steel film electrode with outstanding improved electrochemical and electrical properties had favorable voltammetric characteristics suitable for water treatment or electrochemical analysis.[34–37] Rockwell C indentation test results of DLC films on CoCrMo alloy sheets showed a decrease in spallation, delamination, and cracking areas by doping nitrogen, indicated a slight adhesion improvement and less brittleness of the coating.[27] Also, research on an oxygen reduction reaction process, followed by Zhang et al. achieved a material with high stability to methanol poisoning due to high graphitic N contents and porous structures in the synthesized N-doped coal.[38]
Tailoring of recombinant FDH: effect of histidine tag location on solubility and catalytic properties of Chaetomium thermophilum formate dehydrogenase (CtFDH)
Published in Preparative Biochemistry & Biotechnology, 2019
Hacer Esen, Saadet Alpdağtaş, Mehmet Mervan Çakar, Barış Binay
Formate dehydrogenase (FDH) is an oxidoreductase that catalyzes the conversion of formate into CO2 coupled with the reduction of NAD+ to NADH. These enzymes have attracted great attention due to their various biotechnological applications in different industries. It can be used as a recycler for expensive cofactors (NAD(P)H) in enzymatic synthesis of chiral intermediates such as 6-hydroxybispiron (the main metabolite of Buspirone, a drug used in the treatment of anxiety/depression) and (S)-N-boc-adamantane glycin (a remarkable component of Saxagliptin, type 2 diabetes mellitus drug)[8–10] in pharmaceutical industry. Moreover, it can be utilized for sequestration of greenhouse gases and also used as a formate sensor in different medical applications such as in diagnosis of methanol poisoning, nephrolithiasis, and pathogenic protozoans.[11–14]
Progress towards the ideal core@shell nanoparticle for fuel cell electrocatalysis
Published in Journal of Experimental Nanoscience, 2018
James S. Walker, Neil V. Rees, Paula M. Mendes
In a similar vein, researchers focussing on electrocatalysis for the MOR in DMFCs have observed that while Ru catalysts are more tolerant to methanol poisoning than Pt, they are vulnerable to oxidation. Several works have demonstrated the possibility to make these Ru catalysts more durable by forming alloys of ruthenium selenide, RuSe [52,53]. The mechanism for this improvement in durability has been ascribed to the formation of stable complexes between Ru and Se, which do not oxidise as readily as bare Ru metal.