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Terpenoids: The Biological Key Molecules
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Moumita Majumdar, Dijendra Nath Roy
The expression of genes in immunity, proliferation, differentiation, apoptosis and oncogenesis involve extracellular signal transduction from cell membrane to nucleus, followed by the transcription of DNA through the JAK-STAT signalling pathway. The JAK-STAT signalling comprises three primary components: a cell-surface receptor protein, a Janus kinase (JAK) and two signal transducer and activator of transcription (STAT) proteins (Aaronson and Horvath 2002). Inaccuracy in the regulation of this pathway leads to lethal diseases such as immune deficiency syndromes, inflammatory skin disorders and cancers (Brooks et al. 2014). Cytokines like interferon, interleukin and growth factors bind to cell-surface receptors to trigger the kinase activity of JAKs, resulting in the generation of binding sites for SH2 domains containing STATs. Tyrosine residues of STATs phosphorylate at the receptor site by JAKs to form a hetero- or homodimer and are transmitted to the nucleus for gene expression (Kiu and Nicholson 2012).
Two mixed-ligand coordination polymers: inhibitory effect on renal carcinoma through reducing cancer cells proliferation
Published in Inorganic and Nano-Metal Chemistry, 2021
Qiang Liu, Jing-Jing Sun, Lian-Jun Fan
As above described, CP 1 showed outstanding inhibitory effect on the 769-P renal carcinoma cells proliferation, which is much better than CP 2. However, we further want to explore the detail mechanism of the new CP anti-cancer activity. The JAK-STAT signaling pathway has been reported playing an important role in the cancer cell proliferation and survival. So, the real time RT-PCR was conducted to determine the activation levels of JAK-STAT signaling pathway in the 769-P renal carcinoma cells. As the results showed in Figure 5, we proved that the activation levels of JAK-STAT signaling pathway in the cancer was much higher than the normal cells. CP 1 could significantly reduce the relative expression of the jak and stat. Different from CP 1, CP 2 showed almost no influence on the expression levels of the JAK-STAT signaling pathway.