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Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis
Published in Debasis Bagchi, Manashi Bagchi, Metal Toxicology Handbook, 2020
Bernard W. Downs, Manashi Bagchi, Bruce S. Morrison, Jeffrey Galvin, Steve Kushner, Debasis Bagchi
On the other hand, symptoms of hypophosphatemia include muscle weakness, followed by stupor, coma, and death. During acute hypophosphatemia, phosphate level in blood suddenly goes dangerously low, while during chronic hypophosphatemia, the bones weaken, resulting in bone pain and fractures. People may become weaker and lose their appetite.56,57 The body uses large amounts of phosphate to recover from certain disorders which can cause acute hypophosphatemia.61 Acute hypophosphatemia can also occur in people recovering from physiological conditions such as starvation or severe undernutrition, diabetic ketoacidosis, severe alcoholism, and severe burns.57 A sudden drop in phosphate level causes abnormal heart rhythm and even death. In chronic hypophosphatemia, low phosphate level over an extended period can be caused due to excretion of excessive phosphates from the body.61 Symptoms of hypophosphatemia include hyperparathyroidism and chronic diarrhea. Use of diuretics or aluminum-enriched antacids for a longer period or use of large amounts of theophylline can also aggravate hypophosphatemia.61 It is interesting to note that people who survived concentration camps ultimately died because their already low phosphate level suddenly dropped when these individuals started consuming a normal diet, a phenomenon termed “refeeding syndrome.”61
Solvent free synthesis and spectral analysis of 2,4-dimethyl-6-(1-phenyl-1H-benzimidazol-2-yl)phenol: on/off fluorescence, inter and intramolecular hydrogen bonding
Published in Inorganic and Nano-Metal Chemistry, 2022
Sivapriya J, Ravichandran P, Renganathan S
Iron metal is distributed generously in environmental and biological materials in the form of heme enzymes in hemoglobin and myoglobin and is active in cellular metabolism and enzyme catalysis.[11,12] Iron deficiency is the common reason of anemia whereas its over dosage may cause Alzheimer’s disease and neuroinflammation.[13–17] Phosphate ions, as major constituents of membrane lipids, are essential for skeleton development, energy metabolism, protein synthesis regulation and bone integrity.[18] Phosphate deficiency, a state of hypophosphatemia, may cause rickets and cardiac dysfunction, at the same time, excess phosphates, hyper phosphatemia results in seizures, tetany and tissue calcification.[19] On account of their mentioned significance, for detecting traces of iron and phosphates, the research community is constantly working toward the design and characterization of various fluorescence chemosensor probes.