China 
Africa 
Explore chapters and articles related to this topic
Experimental Results on Cellular and Subcellular Systems Exposed to Low-Frequency and Static Magnetic Fields
Published in Ben Greenebaum, Frank Barnes, Biological and Medical Aspects of Electromagnetic Fields, 2018
Myrtill Simkó, Mats-Olof Mattsson
However, studies showed the induction of HSPs or genes after ELF-MF exposure in primary or non-transformed (“primary-like”) cell lines such as human primary osteoarthritic chondrocytes (Corallo et al. 2014), mouse macrophages (Frahm et al. 2010), transfected rat primary fibroblast (RAT1) cells (Frisch et al. 2013), transfected rat primary cells (Laramee et al. 2014), or cardiomyocytes isolated from neonatal Sprague-Dawley rats (Wei et al. 2016), porcine aortic endothelial cells (Bernardini et al. 2007), endothelial cells (SPAE, HUVECs), and human fibroblasts (HuDe, WI-38) (Alfieri et al. 2006). Considering that the basal level of HSPs expression is strongly cell type dependent, it can be hypothesized that primary cells or primary-like cell lines have a lower basal HSP level; thus, HSPs are rather inductive in non-cancer cells than cancer cell lines. As mentioned above, in a number of cancers such as breast cancer, ovarian cancer, osteosarcoma, endometrial cancer, and leukemias, an increased level of HSP27, and in high-grade malignant tumors such as endometrial cancer, osteosarcoma, and renal cell tumors, HSP70 has been detected, relative to its level in non-transformed cells; see review by Schmitt et al. (2006). Thus, investigations using transformed or tumor cell lines possibly do not show any change after ELF-MF exposure.
Green synthesis of silver nanoparticles using Macrolepiota procera extract and investigation of their HSP27, HSP70, and HSP90 inhibitory potentials in human cancer cells
Published in Particulate Science and Technology, 2023
Aykut Özgür, Özlem Kaplan, Nazan Gökşen Tosun, İbrahim Türkekul, İsa Gökçe
Cancer cells have high metabolic activity and signal transduction; therefore, they require more chaperones than normal cells to maintain proteins for cell survival. HSPs are overexpressed in cancer cells, and they are implicated in metastases, invasion, proliferation, differentiation, and death mechanisms of tumors (Ciocca and Calderwood 2005; Tutar and Ozgur 2014; Chatterjee and Burns 2017). HSP27, HSP70, and HSP90 are essential members of the HSPs family and are involved in the proper folding and stabilization of oncogenic client proteins leading to cancer development and progression. Significantly, the anti-apoptotic function of HSP27, HSP70, and HSP90 has essentially clarified the activation of cytoprotective mechanisms in cancer cells. Overexpression of HSP27, HSP70, and HSP90 inhibits apoptosis and provides cancer cell survival. Therefore, HSPs are remarkable biomarkers in the diagnosis and treatment of various cancer types. The inhibition of HSP27, HSP70, and HSP90 is extensively evaluated as an alternative approach to designing next-generation cancer therapeutics in clinical and experimental studies. Also, metallic nanomaterials may have great potential for inhibiting HSP27, HSP70, and HSP90 in cancer cells (Tutar and Tutar 2010; Murphy 2013; Acunzo et al. 2014; Wang et al. 2014; Sherman and Gabai 2015; Boudesco et al. 2018).