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Poly(Alkyl Cyanoacrylate) Nanoparticles for Delivery of Anti-Cancer Drugs
Published in Mansoor M. Amiji, Nanotechnology for Cancer Therapy, 2006
R. S. R. Murthy, L. Harivardhan Reddy
A procedure for effective and promising preoperative embolization of carotid body tumors was reported by Harman et al.188 Ultrasound-guided direct percutaneous injection of n-butyl cyanoacrylate was given, and angiographic road map assistance was used for protection of parent arteries during the injection. After embolization, complete devascularization of the tumor was achieved without complications. The tumor was removed surgically with minimal blood loss. Transcatheter arterial embolization (TAE) of splanchnic arterial branches to allow continuous application of repeat hepatic arterial infusion chemotherapy (HAIC) was assessed.189 One hundred and twentyeight patients with unresectable advanced liver cancer were implanted with a percutaneous port catheter system and TAE of splanchnic arteries with coils and/or NBCA. The recanalization rate between coil-embolized and NBCA- or NBCA-coil-embolized arteries, and frequency of heterogeneously poor distribution was compared between patients with single arteries and those with multiple hepatic arteries. The arteries once embolized with coils alone spontaneously recanalized at a significantly higher rate than those with NBCA. A hepatic artery embolization study carried out by Loewe et al.186 using NBCA and ethiodized oil for the treatment of small-bowel neuroendocrine metastases to the liver for the treatment of liver metastases from neuroendocrine small-bowel tumors also concluded that the use of cyanoacrylate as an embolic agent is safe and effective.
An update on locoregional percutaneous treatment technologies in colorectal cancer liver metastatic disease
Published in Expert Review of Medical Devices, 2023
Stavros Spiliopoulos, Ornella Moschovaki-Zeiger, Akshay Sethi, George Festas, Lazaros Reppas, Dimitris Filippiadis, Nikolaos Kelekis
Additionally, a few other techniques limited to use in a few centers across the world like hepatic arterial infusion (HAI) of chemotherapy, and percutaneous hepatic perfusion (PHP, or chemosaturation) that employs an organ isolation perfusion system with melphalan, exist as well [5,12].