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Conducting Polymer-Based Micro-Containers for Biomedical Applications
Published in Ram K. Gupta, Conducting Polymers, 2022
Selcan Karakuş, Cemal Özeroğlu, Mizan İbrahim Kahyaoğlu
Dexamethasone phosphate decreases the immune system's response to different diseases to reduce the swelling and allergic-type reactions. Intending to develop these features, it is an anionic corticosteroid drug of choice in controlled release studies. Yasin et al. designed a three-dimensionally ordered macroporous PEDOT thin films using a vapor phase polymerization method with a face-centered cubic structure of 280–290 nm spherical macropores in a PEDOT conductive polymer matrix. The dexamethasone phosphate drug was loaded into three-dimensionally ordered macroporous PEDOT for triggered drug delivery systems and the dexamethasone phosphate release profile was investigated with an alternating pulse stimulation. According to dexamethasone phosphate drug release results, they calculated that the amount of dexamethasone phosphate was released from three-dimensionally ordered macroporous films with a higher amount of 38 ± 25 μg compared to 26.5 ± 5 μg of dexPˉ released from non-templated PEDOT films. Also, the amount of dexamethasone phosphate release was 118 ± 9 μg from the three-dimensionally ordered macroporous films compared to 109 ± 11 μg from the non-templated films [33].
Carbon Nanotubes Used as Nanocarriers in Drug and Biomolecule Delivery
Published in Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani, Drug Delivery Approaches and Nanosystems, 2017
Hua He, Deli Xiao, Lien Ai Pham-Huy, Pierre Dramou, Chuong Pham-Huy
Dexamethasone (DEX) is a synthetic glucocorticoid hormone commonly used as immunosuppressant and antiinflammatory drug to treat many autoimmune and inflammatory diseases. SWCNTs have been used as host-carrier film for the electrically stimulated delivery of DEX. An accelerated cellular uptake and a complete drug release of DEX were observed due to electrostatic repulsions between SWCNTs and DEX when −0.8 V potential was applied. The passive release of DEX was decreased by the addition of SWCNTs, due to the possible attractive interactions between the drug and SWCNTs. This new technique of drug delivery may improve the antiinflammatory therapy of dexamethasone in the future (Luo et al., 2011; Naficy et al., 2009; Tripathi et al., 2015). Ketoprofen, a nonsteroidal antiinflammatory drug (NSAID), is used for the treatment of inflammatory diseases (arthritis, headache, etc.) by its inhibition of the prostaglandin production in the body. An electro-sensitive transdermal DDS, composed of a semiinterpenetrating polymer network (polyethylene oxide-pentaerythritol triacrylate) as the matrix and MWCNTs was demonstrated to increase the electrical sensitivity of (S)-(+)-ketoprofen. The amount of released drug increases with enhanced applied potentials, which can be attributed to higher electrical conductivity of CNTs (Tripathi et al., 2015).
Dexamethasone- loaded polymeric porous sponge as a direct pulp capping agent
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Amjad Alagha, Abdulwahab Nourallah, Sahar Alhariri
Dexamethasone, as known, is a synthetic glucocorticoid used clinically as an anti-inflammatory drug. It has been hypothesized also that dexamethasone increases the response of stem cells to materials used for differentiation [63]. Increased vitality and proliferation of stem cells derived from human bone marrow MSCs have been reported as a result of ongoing dexamethasone therapy [33].