HLA-DQB1

HLA-DQB1

The Etiopathogenesis of Autoimmunity

Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019

The etiology of autoimmune diseases is multifactorial.11,12,20 Many autoimmune diseases are multigenic, with multiple susceptibility genes working in concert ending with an abnormal manifestation or disorder. In many of the different disorders, an increased incidence of B8 or DR2, DR3 or DR4 is found.20 Some HLA alleles protect against the development of autoimmunity even when a susceptibility allele is present. For example, the HLA-DQB1*0602 allele protects against type 1 diabetes.21

Genetic variants affecting chemical mediated skin immunotoxicity

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Journal Information

Published in Journal of Toxicology and Environmental Health, Part B, 2022

Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza, Daniela Morais Leme

The MHC molecules are cell surface glycoproteins whose function is to present peptide antigens to T cells. T cell activation may elicit different types of immune reactions, playing an essential role in pathogenesis of infectious and allergic diseases (Orentas et al. 1990; Posadas and Pichler 2007). The human genes encoding MHC molecules such as human leukocyte antigen and HLA are located in a region that spans approximately 3.6 Mb on 6p21.3, and includes not only classical HLA class I (HLA-A, HLA-B and HLA-C) and II genes (HLA-DRA1, HLA-DRB1, HLA-DPA1, HLA-DPB1, HLA-DQA1 and HLA-DQB1) but also a large number of highly polymorphic genes, encoding proteins with immune-related functions, such as TNF (Alfirevic and Pirmohamed 2011).

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The Etiopathogenesis of Autoimmunity

Genetic variants affecting chemical mediated skin immunotoxicity