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Wound Healing and Inflammatory Response to Biomaterials
Published in Chih-Chang Chu, J. Anthony von Fraunhofer, Howard P. Greisler, Wound Closure Biomaterials and Devices, 2018
P. H. Lin, M. K. Hirko, J. A. von Fraunhofer, H. P. Greisler
While chronic inflammation is generally a result of persistent inflammatory stimuli with the presence of macrophages and lymphocytes, the foreign body reaction and the development of granulation tissue may be considered to be the normal wound healing response to biomaterial implants. Within hours to days of biomaterial implantation, the healing response is initiated by the action of monocytes and macrophages, followed by proliferation of fibroblasts and vascular endothelial cells at the implant site, leading to the formation of granulation tissue, the hallmark of healing. Granulation tissue derives its name from the pink granular appearance on the surface of healing wounds, with its characteristic histologic features including the proliferation of new small blood vessels and fibroblasts. Depending on the extent of the inflammatory response, granulation tissue may appear as early as 3 to 5 days after implantation of a biomaterial.
Advances in Nanonutraceuticals: Indian Scenario
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Amthul Azeez, Mubeen Sultana, Lucky, Noorjahan
Sofaniim incanum - Bitter apple and thorn apple have wound healing properties. In a burn wound, the damage occurring to the epidermis is restored by the process of reepithelization in which keratinocytes move from the lower layer of the skin and form mature cells that cover the wound bed. The signs of proper wound healing are healthy granulation tissue, sebaceous glands and new blood vessels. Sofaniim incanum promotes movement and differentiation of keratinocytes, new connective tissue and blood vessel formation which are the important features of healthy granulated tissues proving the best healing property. It also contains tannins and flavonoids which are responsible for wound healing activity and stimulates wound healing at cellular and tissue level.
Skin image analysis granulation tissue for healing assessment of chronic ulcers
Published in Ahmad Fadzil Mohamad Hani, Dileep Kumar, Optical Imaging for Biomedical and Clinical Applications, 2017
Ahmad Fadzil Mohamad Hani, Leena Arshad
Granulation tissue appears as red when viewed under the visible light due to the pigment haemoglobin present in the newly formed blood capillaries within the tissue [23]. This is because the haemoglobin pigment (both oxy-haemoglobin and deoxy-haemoglobin) gives off a reflection of the light in the range of 600 nm and above, as shown in Figure 2.6, which corresponds to the red colour component in the visible light spectrum [21].
A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing
Published in Journal of Biomaterials Science, Polymer Edition, 2022
As a result, Wang et al [18] prepared hyaluronic acid-catechol based hydrogels through the grafting of dopamine hydrochloride onto hyaluronic acid using scallops as tissue adhesives as well as triggers of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). Moreover, the presence of these enzyme-mediated crosslinking made it possible for rapid gelation to occur at neutral pH and room temperature. The study aimed to develop novel water-proof tissue adhesives, since perforated scallop adhesion depends on catechol. The prepared hydrogel enhanced wound repair via formation of granulation tissue and collagen metabolism. Granulation tissue is the first construction in the process of skin wound healing and it is made up of tiny blood vessels and connective tissue [174]. However, recent advances have indicated that several chemical agents hold potential for rapid wound sealing. Examples of experimental chemical agents for wound healing include fibrin glue, gelatin, collagen, oxidized cellulose, zeolites, peptides, polymers and hydrogels [175,176].
Influence of sequential opening/closing of interface gaps and texture density on bone growth over macro-textured implant surfaces using FE based mechanoregulatory algorithm
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2022
Rajdeep Ghosh, Souptick Chanda, Debabrata Chakraborty
The interfacial gap between the host bone and the implant was primarily assumed to be filled with a soft homogeneous medium, known as ‘granulation tissue’ (Gardner et al. 2000; Lacroix et al. 2002; Ghimire et al. 2021). It should be emphasized, however, that when tissue differentiation occurs on the iterative timeframe, the initial state of granulation tissue homogeneity will cease out (Ghosh et al. 2021). Granulation tissue is filled with sufficient blood vessels formed by angiogenesis to supply nutrients to the newly formed cells and inflammatory cells to remove injured portion of the tissue. The progressive bone growth phenomenon was simulated using a mechanoregulatory scheme (Figure 3) developed earlier (Ghosh et al. 2020) that simulated the migration of multipotent stromal cells, also referred as mesenchymal stem cells (MSCs), from the bone site within the region of soft granulation tissue using a transient-diffusion model as in Eq. 1: where k (0.1 mm3/day) is a constant of diffusion, c is the element-specific concentration of stem cells. A constant healing phase of T′=120 days or approximately 4 months was chosen for the migration of stromal cells for all the analysis in the present study. No-flux condition was considered at the peripheral surfaces of the tissue, which represents no cellular loss from the tissue (Ghosh et al. 2020). The concentration of other cells, insignificant for tissue differentiation, in the granulation tissue is assumed to be zero (Andreykiv et al. 2008; Puthumanapully 2010; Mukherjee and Gupta 2017a). The concentration of stromal cells at the bone interface (cmax) was assumed to be unity (1.0).
Recent advancements in the minimally invasive management of esophageal perforation, leaks, and fistulae
Published in Expert Review of Medical Devices, 2019
Shirin Siddiqi, Dean P. Schraufnagel, Hafiz Umair Siddiqui, Michael J. Javorski, Adam Mace, Abdulrhman S. Elnaggar, Haytham Elgharably, Patrick R. Vargo, Robert Steffen, Saad M. Hasan, Siva Raja
With the use of Fibrin glue, granulation tissue ideally forms within 3 days, with and collagen fibers within a week, promoting closure of the leak [107]. Cyanoacrylate is not widely used because it has been unsuccessful in closing leaks measuring greater than 10 mm and has rarely been reported in sealing esophageal leaks greater than 4 mm [77,106,108]. Tissue sealants can be combined with other endoscopic techniques such as stents or clips for optimal results.