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Nutraceutical Efficiency of Fucan Polysaccharides from Marine Sources
Published in Shakeel Ahmed, Aisverya Soundararajan, Marine Polysaccharides, 2018
Ashwini Rav, S. Vijayanand, S. Aisverya, P. N. Sudha, J. Hemapriya
Studies on hepatoprotective activity of fucan or fucoidan have been conducted in mice, Wistar rat models and also cell lines. The animal models were administered CCl4 and D-galactosamine to cause liver injury. Then they are treated with fucans and observed for their hepatoprotective activity. It was found that in the animal models treated with fucans, elevation of gluatamate pyruvate transaminase which is produced by oxidative stress was inhibited, the level of antioxidant enzymes was reverted to normal, the level of lipid peroxidation markers decreased, the inhibition of glutathione peroxidase and glutathione S transferase decreased, the liver enzymes reverted to normal production and the damage caused by necrosis and cirrhosis was repaired. From these findings, it has been proven that fucan can act as a potent hepatoprotective agent [112, 124–127].
Recent Developments in Bioresponsive Drug Delivery Systems
Published in Deepa H. Patel, Bioresponsive Polymers, 2020
Drashti Pathak, Deepa H. Patel
Ringsdorf also suggested that a targeting moiety could be incorporated into the polymer to enhance uptake by receptor-mediated endocytosis. This was shown by the polymer therapeutic PK2, which is composed of HPMA copolymer-Gly-Phe-Leu-Gly-DOX incorporating galactosamine. The galactosamine residue enhances uptake of the conjugate by the liver by targeting the hepatocyte asialoglycoprotein (ASGP) receptor, thus it was investigated as a treatment for liver cancer [1].
Effects of biochar on the accumulation of necromass-derived carbon, the physical protection and microbial mineralization of soil organic carbon
Published in Critical Reviews in Environmental Science and Technology, 2023
Yalan Chen, Ke Sun, Yan Yang, Bo Gao, Hao Zheng
The traditional understanding of the formation of soil C pools based on “plant residue humification” has been widely refuted in soil science. Increasing evidence shows that microbial necromass carbon (MNC) is an important component of soil stable C pools, accounting for over 50% of SOC pools and approximately 40 times the microbial live C (Liang et al., 2017). The theoretical framework of the "microbial C pump" emphasizes the decomposition and transformation of plant-derived C by microbes, as well as the stabilization of microbial metabolites and dead residues in the soil. Four types of amino sugars, including glucosamine (GluN), muramic acid (MurA), mannosamine (ManN), and galactosamine (GalN), as typical biomarkers of soil MNC, to evaluate the contribution of MNC to C accumulation and turnover in various habitats.
Unified Dosimetry Quality Audit Index: an integrated Monte Carlo model-based quality assurance ranking for radiotherapy treatment of glioblastoma multiforme
Published in Radiation Effects and Defects in Solids, 2023
Praveen Kumar C, Lalit M. Aggarwal, Saju Bhasi, Neeraj Sharma
GBM 36, GBM 37 (70): The composition of pus fundamentally mucin are glycoprotein fraction, fucose, galactose, N-acetyl galactosamine, N-acetyl glucosamine, sialic acid, sulfate and divalent cations of zinc, iron, calcium, magnesium, copper and selenium.The elemental composition for pus was accounted from its constituents as H = 0.0660570071, C = 0.411614309, N = 0.060088405, O = 0.441711156, S = 0.020288994, Ca = 0.0000252, Fe = 0.0000185, Cu = 0.000001, Zn = 0.0000058 and Se = 0.00000013. Pus recorded a value of +40 Hounsfield unit. GLPS521 slab in the phantom assigned with a density value of 1.048046 gm/cm3 derived from the Hounsfield scale adopting, lagrangian interpolation. The calculated mean excitation energy was in the range of 77.1(eV). Slab dimensions for GLPS521 were deteremined by assuming a circular locus of abscess with diameter 3.1 cm. Computed slab dimensions were R = 2.4232 cm and Z = 3.113 cm.
Adsorption of tetracycline by Nicandra physaloides (L.) Gaertn seed gum and Nicandra physaloides(L.) Gaertn seed gum/Carboxymethyl chitosan aerogel
Published in Environmental Technology, 2022
Liubo Li, Yanhui Li, Meixiu Li, Yong Sun, Huimin Wang, Mingfeii Cui, Wenshuo Xu
Nicandra physaloides (L.) Gaertn seed gum (NPG) is secreted by Nicandra physaloides (L.) Gaertn (NP) seeds in contact with water and it is a pure polysaccharide that is connected by 1–4 glycosidic bonds. NPG consists of glucosamine (1.69%), mannose (3.25%), rhamnose (4.74%), galactosamine (2.01%), galacturonic acid (55.18%), galactose (5.9%), arabinose (0.91%), glucose (20.64%), xylose (3.05%). And rhamnose, galactose, glucose and galacturonic acid are the four main monosaccharides of NPG, and their molar ratio is 1:1:4:12 [37,38]. The molecular weight of NPG is 1.6·106 and NPG contains galacturonic acid, so adding a small amount of Cu2+ leads to bridging and contributes to the three-dimensional network structure[39,40,41]. NPG has been used in the fields of medicine, food and cosmetics and so on. However, it is rarely used in the field of adsorption.